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99,167 grants found
Showing 97,881 – 97,900 of 99,167 grants
Role of MIF and CD74 in the pathogenesis of emphysema
PROJECT SUMMARY Emphysema is a common pathologic manifestation of Chronic Obstructive Pulmonary Disease (COPD), the fourth leading cause of death in the United States. The most imp...
Understanding the function of histone H3 as an oxidoreductase enzyme
PROJECT SUMMARY This application proposes to investigate the newly discovered function of histone H3 as an oxidoreductase enzyme, catalyzing the reduction of cupric (Cu+2) ions to...
Mechanism of cardiovascular disease in premenopausal women
PROJECT SUMMARY Suboptimal nutrition is the leading risk factor for death and disability worldwide and accounts for accounts for more than 45% of cardiovascular death in the US. D...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality. Despite the best available treatments, prognosis remains poor for many HF patients under...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S. Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS ?Tobacco Heating System? (IQOS), manufactured by Phill...
Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging
PROJECT SUMMARY . There are numerous clinical needs for a technology that can modulate nervous system activity noninvasively and focally, with clinically-relevant spatial and tempo...
Non-invasive, Transgene-free, on-demand Pharmacological Modulation of Neural Activity
PROJECT SUMMARY/ABSTRACT Cell-type specific manipulation of neural circuits is required for the treatment of neurological disorders such as epilepsy and autism. Existing technologi...
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of...
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA?approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly g...
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease
The precise regulation of the body's phosphate homeostasis is a critical task. Treatment of hyperphosphatemia, which becomes inevitable in later stages of chronic kidney disease (C...
Pathologic Signaling Pathways in AML Cells
Abstract: Acute myeloid leukemia (AML) is a serious blood cancer that affects United States Veterans and other individuals. Multiple studies have demonstrated that active signaling...
Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementia
PROJECT SUMMARY/ABSTRACT Appropriate use of acetylcholinesterase (AChEIs) and memantine can meaningfully improve the health outcomes and quality of life among people with Alzheimer...
Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
PROJECT SUMMARY/ABSTRACT Vascular calcification, especially coronary artery calcification (CAC), is associated with increased risk of cardiovascular disease, whereas regular physic...
Neighborhoods, Sexual Orientation, Race/Ethnicity & Smoking Across the Adult Lifespan: A Multilevel Intersectional Assessment
Abstract/Project Summary Recent estimates indicate that 11.3 million adults in the United States identify as sexual and/or gender minorities (SGMs) and of these 2.3 million are ag...
Superresolution Light Sheet Microscopy for imaging model organisms with 200nm resolution
Project Summary Light Sheet Microscopy has become an essential tool for investigating a wide variety of biological problems from developmental questions to mapping neural circuits....
The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivo
PROJECT SUMMARY/ABSTRACT Pancreatic ?-cells within the islets of Langerhans are required for glucose-stimulated insulin secretion and glucose homeostasis. Dysfunctional ?-cell act...
Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction
PROJECT SUMMARY This proposal is a new application entitled Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction. The question of...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population. Approximate...
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an est...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head in...