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99,167 grants found
Showing 97,821 – 97,840 of 99,167 grants
Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
PROJECT SUMMARY Nociceptor neurons are peripheral sensory neurons that densely innervate the gastrointestinal tract, detecting noxious/harmful stimuli to mediate protective neura...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to ci...
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally o...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated varian...
Analysis of conserved eukaryotic transcription elongation factors
PROJECT SUMMARY/ABSTRACT The long-term objectives of this project are to increase our understanding of eukaryotic transcription elongation, with a focus on histone chaperones. Hi...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional sele...
Cell cycle dependent mechanisms triggering lumen formation in vivo
SUMMARY STATEMENT: In humans and other vertebrates, motile cilia located in an organ of asymmetry play an important role in cardiac left-right development. Evidence from model org...
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA‐approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly...
Hydrogen peroxide in endothelial function and dysfunction
The parent R01 grant for this Administrative Supplement is supporting studies of an experimental program that uses chemogenetic approaches to define the roles of reactive oxygen s...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Alzheimer’s disease (AD) is the most common form of dementia and its prevalence is increasing as the world population ages. Interestingly, AD shares man...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributio...
Understanding and Targeting Tiam1 in Cancer
Project Summary: Understanding the detailed mechanisms that underlie proliferative signal transduction pathways is of critical importance for developing strategies for diagnosis an...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. T...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
Project Summary Physical inactivity is a public health priority for older Latinos with mild cognitive impairment (MCI). MCI, considered the pre-dementia stage of Alzheimer?s diseas...
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration. Many studies have demonstrated...
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
PROJECT SUMMARY: Inflammatory bowel disease (IBD) is an increasingly prevalent disease that currently affects ~1.3% of adults in the US. IBD is characterized by chronic inflammator...
PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping
Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally. However, a vital step for EHR-based research is valid, accurate, and reliable...
Role of Protein Kinase C Mutations in Adult T-Cell Leukemia
Abstract - Role of Protein Kinase C Mutations in Adult T-Cell Leukemia Human T-cell leukemia virus type 1 (HTLV-1) is the cause of a T cell lymphoproliferative disorder, designate...