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99,167 grants found
Showing 97,781 – 97,800 of 99,167 grants
Multi Biomarker-based prediction tool development to determine risk of infections-related outcomes among severe blunt trauma patients
Severe trauma injury renders patients vulnerable to infections and subsequent risk of infections-related outcomes, including multiple organ failure/dysfunction syndrome (MOF/MODS)...
Durability of Epithelial Defects in Crohn's Disease Intestine
PROJECT SUMMARY/ABSTRACT Crohn’s disease is a debilitating and progressive inflammatory disease of the gastrointestinal tract. Defects in epithelial cells are thought to contribu...
1/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa pop...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population. Approximat...
Harnessing acid-sensing ion channel toxins for therapeutic purposes
PROJECT SUMMARY/ABSTRACT Generalized anxiety and panic disorder are debilitating disorders resulting in severe social and economic impact for patients. Antidepressants and benzo...
Patient-Specific Strategies for Capsular Repair Following Shoulder Dislocations
Project Summary Traumatic dislocation of the shoulder is an injury that commonly affects young athletes and has been associated with recurrent instability despite surgical repair...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it. This research wil...
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disor...
Redefining hemophagocytic lymphohistiocytosis in hematologic malignancies
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that is increasingly recognized in patients with malignancies (M-HLH). However, nearly early e...
Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework
Project Summary / Abstract The proposed research aims to develop novel causal inference methods to resolve unmeasured confounding bias known to plague vaccine effectiveness and s...
Role of membrane-associated macrophages in health and inflammation
PROJECT SUMMARY/ ABSTRACT Mesenteritis is an inflammatory disorder of mesenteric tissues. It includes mesenteric lipodystrophy (mesenteric fat necrosis), mesenteric panniculitis...
Epigenomics of asthma risk factors and clinical subtypes in minority children
PROJECT SUMMARY Asthma is the most common chronic disorder of children, with an estimated 300 million cases worldwide and with significant increases in incidence since the early...
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally o...
Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women
Project Summary/Abstract African American women are 60% more likely to have postpartum hypertension and are nearly three times more likely to die from preeclampsia than white wom...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologi...
Repurposing Endonuclease V for the detection and engineering of adenosine-to-inosine editing
Project Summary/Abstract RNA editing is a widespread strategy employed by cells to post-transcriptionally alter protein sequence and gene expression levels. Adenosine-to-inosine...
Discovery and development of artificial nucleic acid ligands to probe cellular interactions
Discovery and development of artificial nucleic acid ligands to probe cellular interactions The regulation followed by measurement of cellular events, such as intercellular commun...
Lateral habenula circuit dysregulation in mild traumatic brain injury
Summary Traumatic brain injury (TBI) contributes to almost 30% of all injury-related deaths in the United States, but the majority of TBI injuries are mild (mTBI). Anxiety, depre...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal...
Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation
Project Summary/Abstract Challenges exist in bioremediation of halogenated contaminants, including low donor utilization efficiency and slow dehalogenation, low dehalogenation ac...