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99,167 grants found
Showing 97,721 – 97,740 of 99,167 grants
Enhancing bioremediation of groundwater co-contaminated by chlorinated volatile organic compounds and 1,4-dioxane using novel macrocyclic materials
Project Summary The project addresses a common challenge in the remediation of groundwater contaminated with chlorinated volatile organic compounds (CVOCs) and 1,4-dioxane. CVOC...
Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
PROJECT SUMMARY/ABSTRACT Vascular calcification, especially coronary artery calcification (CAC), is associated with increased risk of cardiovascular disease, whereas regular phys...
Modeling myelodysplasia
PROJECT SUMMARY Myelodysplastic Syndromes (MDS) are a cancer of the hematopoietic stem cell (HSC) on the rise in the aging population and cancer survivors. The only curative trea...
Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)
Project Summary The recalcitrant and harmful chemicals such as PFASs (per- and polyfluoroalkyl substances), endangers the environmental, wild-life, and human health profoundly. A...
Diagnosing and predicting risk in children with SARS-CoV-2- related illness
In the wake of COVID-19 pandemic, Multisystem Inflammatory Syndrome in Children (MIS-C) has evolved as a new threat to children exposed to SARS-CoV-2. The emergence of MIS-C is so...
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
The novel coronavirus SARS-CoV-2 is causing significant morbidity and mortality. Current approaches to SARS- CoV-2 testing are costly, inconsistently implemented, and fail to rapi...
Improved scalability, sensitivity, and interpretability of pathogen detection, including SARS-CoV-2, in wastewater using high-throughput, highly multiplexed digital array PCR technology
PROJECT ABSTRACT Presently, the application of molecular technology such as RT-qPCR and digital PCR (dPCR) to quantify SARS-CoV-2 and related targets in wastewater is cumbersome,...
COVID-19 Network of Networks Expanding Clinical and Translational approaches to Predict Severe Illness in Children (CONNECT to Predict SIck Children)
The SARS-CoV-2 pandemic has manifested in children with a wide spectrum of clinical presentations ranging from asymptomatic infection to devastating acute respiratory symptoms, ap...
Wastewater Analysis of SARS CoV-2 in Tribal Communities
ABSTRACT The rapid onset of the COVID-19 pandemic left many across the world unprepared to test, treat, and plan for coronavirus morbidity and mortality. This was true for Tribal...
Wastewater Assessment for Coronavirus in Kentucky: Implementing Enhanced Surveillance Technology
Wastewater Assessment for Coronavirus in Kentucky – Implementing Enhanced Surveillance Technology Surveillance for SARS-CoV-2 is hindered by the availability of testing, particul...
A data science approach to identify and manage Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection and Kawasaki disease in pediatric patients
Summary – Since the SARS-CoV-2 pandemic began, the emergence of an associated novel multisystem inflammatory syndrome in children (MIS-C) has been reported. Interestingly, patient...
Development and Proof-of-Concept Implementation of the South Florida Miami RADx-rad SARS-CoV-2 Wastewater-Based Surveillance Infrastructure
PROJECT SUMMARY The University of Miami (UM), with three primary campuses in Miami, Florida, is geographically spread within one of the worst current COVID-19 hotbeds. UM has dep...
The pursuit of genetic causal mechanisms
Project Summary Recent years have witnessed the development of large research projects that involve genotyping hundreds of thousands of individuals, on which we have available...
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19
ABSTRACT Novel approaches for early and accurate diagnosis of COVID-19 associated syndromes and evaluation of clinical severity and outcomes of COVID-19 disease in children are u...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributi...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has sprea...
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
PROJECT SUMMARY / ABSTRACT Nontuberculous mycobacterial lung diseases, primarily due to M. avium complex (MAC), is an increasing clinical problem nationwide and now overtakes dom...
Epigenetic dysregulation in diabetic enteric neuropathy
Diabetic gastroenteropathy includes asymptomatic delayed gastric emptying, dyspepsia with or without mildly delayed gastric emptying, or gastroparesis, which is characterized by m...
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease Principal Investigators: Chong Wu, Ph.D. (contact); Jonathan Bradley, Ph.D. Summary A fundamen...
Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors
Sialylated glycans are involved in complex regulation and signaling and play a critical role in disease. In the virus life cycle, receptor binding and sialic acid cleavage to faci...