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99,167 grants found
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AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids
This work is directed at characterizing pediatric COVID-19 and stratifying incoming patients by projected (future) disease severity. Such stratification has several implications:...
Diagnosis of MIS-C in febrile children
PROJECT SUMMARY The recent emergence of SARS-CoV-2 and resultant pandemic of COVID-19 disease has overwhelmed global health systems and led to over 200,000 American deaths to dat...
Severity Predictors Integrating salivary Transcriptomics and proteomics with Multi neural network Intelligence in SARS-CoV2 infection in Children (SPITS MISC)
Abstract Children have been disproportionately less impacted by the Corona Virus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SAR-CoV-2...
Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)
PROJECT SUMMARY / ABSTRACT In adults, SARS-CoV-2 infection exhibits a wide range of clinical outcomes, from asymptomatic and mild disease to severe viral pneumonia, respiratory d...
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
Project Summary/Abstract Calcium activated Chloride Channels (CaCCs) and other TMEM16 family members form ion channels and/or lipid scramblases that help orchestrate a large numb...
Mechanism of cardiovascular disease in premenopausal women
PROJECT SUMMARY Suboptimal nutrition is the leading risk factor for death and disability worldwide and accounts for accounts for more than 45% of cardiovascular death in the US....
Understanding the function of histone H3 as an oxidoreductase enzyme
PROJECT SUMMARY This application proposes to investigate the newly discovered function of histone H3 as an oxidoreductase enzyme, catalyzing the reduction of cupric (Cu+2) ions...
CCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastoma
PROJECT SUMMARY Brain tumors are the most common solid tumor and the leading cause of cancer-related death in children. Medulloblastoma (MB) is the most common malignant pediatri...
Renal AT2 Receptors in Hypertension
PROJECT SUMMARY/ABSTRACT Hypertension (HT) affects ~48% of the US population. Increased renal sodium (Na+) retention is a major contributor to the development of HT. The renal an...
Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
PROJECT SUMMARY/ABSTRACT Development of effective therapies is an urgent unmet medical need for patients with metastatic gastroesophageal adenocarcinoma (mGEA). The advent of imm...
Activity-dependent regulation of Sonic hedgehog signaling incortical astrocytes
PROJECT ABSTRACT Understanding the mechanisms by which the CNS adapts to novel experiences and changing environments is a fundamental goal of neuroscience. Following experience a...
The role of mitochondria in hematopoietic stem cell self-renewal
Abstract Hematopoietic stem cells (HSC) sustain the production of all blood and immune cells throughout life by differentiating into all blood lineages and regenerate long-lived...
Hydrogen peroxide in endothelial function and dysfunction
The proposed studies will use new biosensors and novel chemogenetic approaches to identify the molecular mechanisms whereby reactive oxygen species (ROS) regulate nitric oxide (NO...
Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal Cord
Injury to the cervical spinal cord results in an immediate and permanent loss of hand function due to massive disruption of neural circuitry. There are currently no effective ther...
Traumatic Axonopathy in the CNS as Wallerian degeneration
PROJECT SUMMARY In this application we propose that traumatic axonal injury (TAI) leads to an active axonopathy with the molecular features of Wallerian degeneration and that tar...
Novel Strategies for Treating Biofilm-Forming Pathogens with Phage Therapy
Project Summary The growing antibiotic resistance problem requires that we urgently develop and test new approaches to controlling bacterial infections. Phage therapy approaches...
Exploiting sex-dependent brain injury response for nanoparticle therapeutics
Abstract Traumatic brain injury (TBI) afflicts over 1.7 million persons per year in the U.S. alone, resulting in substantial economic burden annually. To date, despite promising...
Pharmacological modulation of striatal physiology and repetitive behaviors by M4 PAMs
Project Summary / Abstract Repetitive behaviors are commonly observed in disorders such as Obsessive-Compulsive Disorder (OCD), Tourette’s Syndrome (TS), and Autism Spectrum Diso...
Cellular and molecular mechanisms underlying DDX3X syndrome
Abstract Mutations in DDX3X are strongly associated with autism spectrum disorder (ASD), and may account for 1-3% of unexplained developmental delay (DD) in females, making this...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immun...