Browse All Grants
99,167 grants found
Showing 97,661 – 97,680 of 99,167 grants
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes. The tumor suppressor protein p53 is a transcription factor orchestrat...
Nanochelation Therapies for Iron Overload Disorders
PROJECT SUMMARY/ABSTRACT Iron overload, best represented by hereditary hemochromatosis (primary/genetic iron overload) and transfusional hemoglobinopathy (secondary/acquired iron o...
Network-based algorithms for target identification and drug repositioning from genetic associations
In the field of genetics, genome-wide association studies of common variants (GWAS) and exome sequencing- based analyses are a common strategy to elucidate the relationship between...
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
PROJECT SUMMARY The goal of this study is to examine the functions of the zinc finger protein ZPR1 in R-loops metabolism and neurodegeneration. R-loops are formed during transcript...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response...
Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial
PROJECT SUMMARY Aging, obesity, diabetes, hypertension and other risk factors associated with abnormal lipid and carbohydrate metabolism are risk factors for death in Coronavirus d...
Molecular mechanisms of exocytotic vesicle fusion and release.
Fusion of membrane bound vesicles with a target membrane is of ubiquitous importance for cellular function from intracellular trafficking to exocytotic release of various mediators...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10 years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and p...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)—the only randomized controlled trial (RCT) comparing foster care to institutional care for young children...
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease
The precise regulation of the body's phosphate homeostasis is a critical task. Treatment of hyperphosphatemia, which becomes inevitable in later stages of chronic kidney disease (...
Structure and Function of Primate Retinal Circuits
An understanding of the normal structure and function of the retina is important to appreciate changes that occur during disease, development and aging. To this end, a longstandin...
Regulation of the neuroinflammatory response in autoimmune uveitis
Research Abstract: Autoimmune uveitis is a serious sight-threatening condition defined by an autoreactive immune response against the retina and uveal tissues. In autoimmune uveit...
Mitochondrial pyruvate transport in retinal health and disease
PROJECT SUMMARY/ABSTRACT The retina is the most metabolically active neuronal tissue in the human body. The defect in the energy metabolism of photoreceptor neurons and their sup...
Targeting polyamines to suppress SARS-CoV-2 related disease
ABSTRACT The pandemic COronaVIrus disease 2019 (COVID-19) is an infectious disease, which is caused by a novel and highly pathogenic virus strain SARS-CoV-2 (Severe acute respira...
Superresolution Light Sheet Microscopy for imaging model organisms with 200nm resolution
Project Summary Light Sheet Microscopy has become an essential tool for investigating a wide variety of biological problems from developmental questions to mapping neural circuit...
SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population
This proposal seeks to address a key challenge in public health : the ongoing and fine-grained measurement of population mental health. Currently, in the largest population survey...
Molecular mechanisms of excitatory postsynaptic diversity
Unique patterns of synaptic connectivity between neurons, and the differential strength of those synapses, are fundamental to the information processing capability of the brain. S...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amy...
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate Eye
The importance for vision of the tiny fovea has been established by centuries of investigation as well as observations of the devastating consequences of its damage through injury...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local...