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Showing 97,58197,600 of 99,167 grants

Completed NON-SBIR/STTR RPGS
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomes
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Sloan-Kettering Inst Can Research United States 2021 – 2025

ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for most forms of acute myelogenous leukemia (AML), but its 50% failure rate remains u...

$5.84M
USD
Completed NON-SBIR/STTR RPGS
Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac Arrest
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Columbia University Health Sciences United States 2021 – 2025

With advances in healthcare and effective public health campaigns, the survival rate after cardiac arrest (CA) has more than doubled during the last decade. However, as highlighte...

$7.14M
USD
Completed NON-SBIR/STTR RPGS
MIRA: The biological basis of paternal care in stickleback fish
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Illinois At Urbana-Champai... United States 2021 – 2025

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The Abstract is unchanged. Parental care is c...

$3.86M
USD
Active NON-SBIR/STTR RPGS
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
NATIONAL CANCER INSTITUTE University of Virginia United States 2021 – 2026

PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC). Distur...

$2.49M
USD
Completed NON-SBIR/STTR RPGS
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomes
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Sloan-Kettering Inst Can Research United States 2021 – 2024

ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for most forms of acute myelogenous leukemia (AML), but its 50% failure rate remains una...

$6.5M
USD
Completed NON-SBIR/STTR RPGS
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Texas A&M Agrilife Research United States 2021 – 2021

ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY Despite serious pregnancy complications, 50% of women who use tobacco products will continue to do s...

$1.21M
USD
Completed NON-SBIR/STTR RPGS
Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac Arrest
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Columbia University Health Sciences United States 2021 – 2025

With advances in healthcare and effective public health campaigns, the survival rate after cardiac arrest (CA) has more than doubled during the last decade. However, as highlighted...

$8M
USD
Completed NON-SBIR/STTR RPGS
MIRA: The biological basis of paternal care in stickleback fish
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Illinois At Urbana-Champai... United States 2021 – 2025

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The Abstract is unchanged. Parental care is cri...

$3.86M
USD
Completed NON-SBIR/STTR RPGS
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY.
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Wayne State University United States 2021 – 2024

ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY Despite serious pregnancy complications, 50% of women who use tobacco products will continue to do...

$4.02M
USD
Completed NON-SBIR/STTR RPGS
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2022

Men are 3-5 times more likely than women to develop and die from bladder cancer (BCa) but the underlying mechanisms of these gender disparities in BCa are poorly understood. This i...

$2.34M
USD
Completed NON-SBIR/STTR RPGS
Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Colorado Denver United States 2021 – 2025

PROJECT SUMMARY. Despite knowing for more than 60 years that three copies of chromosome 21 (chr21, T21) is the genetic cause of Down syndrome (DS), we still know relatively littl...

$1.95M
USD
Completed NON-SBIR/STTR RPGS
Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Colorado Denver United States 2021 – 2025

PROJECT SUMMARY. Despite knowing for more than 60 years that three copies of chromosome 21 (chr21, T21) is the genetic cause of Down syndrome (DS), we still know relatively little...

$19.19M
USD
Completed NON-SBIR/STTR RPGS
Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunity
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Texas Med Br Galveston United States 2021 – 2022

PROJECT SUMMARY Precise and dynamic alterations in gene expression are critical determinants of the regulation of host immunity to microbial pathogens. Pathogenic rickettsiae in th...

$2.37M
USD
Completed NON-SBIR/STTR RPGS
Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunity
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Texas Med Br Galveston United States 2021 – 2024

PROJECT SUMMARY Precise and dynamic alterations in gene expression are critical determinants of the regulation of host immunity to microbial pathogens. Pathogenic rickettsiae in...

$1.98M
USD
Completed NON-SBIR/STTR RPGS
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2023

Men are 3-5 times more likely than women to develop and die from bladder cancer (BCa) but the underlying mechanisms of these gender disparities in BCa are poorly understood. This...

$1.91M
USD
Completed NON-SBIR/STTR RPGS
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
NATIONAL CANCER INSTITUTE University of Rochester United States 2021 – 2025

Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive imp...

$2.49M
USD
Completed NON-SBIR/STTR RPGS
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
NATIONAL CANCER INSTITUTE University of Rochester United States 2021 – 2025

Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive imp...

$1.57M
USD
Completed NON-SBIR/STTR RPGS
Aging-Related Biomarkers of Neurocognitive Function in Long-term Hodgkin Lymphoma Survivors
NATIONAL CANCER INSTITUTE University of Rochester United States 2021 – 2025

Abstract Emerging evidence suggests that childhood cancer survivors treated without central nervous system (CNS) directed therapies are at significant risk for neurocognitive imp...

$2.49M
USD
Completed NON-SBIR/STTR RPGS
Transcriptome-driven inference of adverse drug interactions
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICA... Seattle Children'S Hospital United States 2021 – 2023

ABSTRACT Ototoxicity is a debilitating side effect of over 150 medications, many of which are prescribed as part of multi- drug regimens to treat a broad range of conditions incl...

$1.86M
USD
Completed NON-SBIR/STTR RPGS
Transcriptome-driven inference of adverse drug interactions
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICA... Seattle Children'S Hospital United States 2021 – 2023

ABSTRACT Ototoxicity is a debilitating side effect of over 150 medications, many of which are prescribed as part of multi- drug regimens to treat a broad range of conditions includ...

$1.86M
USD