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Showing 97,56197,580 of 99,167 grants

Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2024

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity. We will create a detailed and systemic view of defined pancreatic nerves,...

$5.95M
USD
Completed NON-SBIR/STTR RPGS
Live Imaging of Immunity to M. tuberculosis
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of California, San Francisco United States 2021 – 2023

Project Summary Tuberculosis (TB), caused by the bacterium, Mycobacterium tuberculosis, kills more humans every year than does any other infectious disease, including HIV. Among...

$1.01M
USD
Completed NON-SBIR/STTR RPGS
Immune response to inhalation of live attenuated vaccine in an outbred tularemia model (Resubmission)
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Pittsburgh At Pittsburgh United States 2021 – 2024

Tularemia is a severe zoonotic disease in humans with fatality rates exceeding 30% in untreated subjects. Francisella tularensis, the causative organism, is a gram-negative coccob...

$2.23M
USD
Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2024

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity. We will create a detailed and systemic view of defined pancreatic nerves,...

$5.95M
USD
Completed NON-SBIR/STTR RPGS
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Michigan State University United States 2021 – 2024

Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue...

$4.45M
USD
Completed NON-SBIR/STTR RPGS
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Michigan State University United States 2021 – 2025

Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue...

$4.54M
USD
Completed NON-SBIR/STTR RPGS
The Role of PHF6 in HSC self-renewal and myeloid expansion
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Pennsylvania United States 2021 – 2025

Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal...

$5.22M
USD
Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2025

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity. We will create a detailed and systemic view of defined pancreatic nerves,...

$5.71M
USD
Completed NON-SBIR/STTR RPGS
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
NATIONAL HUMAN GENOME RESEARCH INSTITUTE Massachusetts Institute of Technology United States 2021 – 2025

Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME ha...

$5.28M
USD
Completed NON-SBIR/STTR RPGS
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY.
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Wayne State University United States 2021 – 2024

ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY Despite serious pregnancy complications, 50% of women who use tobacco products will continue to do s...

$2.23M
USD
Completed NON-SBIR/STTR RPGS
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomes
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Sloan-Kettering Inst Can Research United States 2021 – 2024

ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for most forms of acute myelogenous leukemia (AML), but its 50% failure rate remains u...

$6.08M
USD
Completed NON-SBIR/STTR RPGS
MIRA: The biological basis of paternal care in stickleback fish
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Illinois At Urbana-Champai... United States 2021 – 2025

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The Abstract is unchanged. Parental care is c...

$3.86M
USD
Completed NON-SBIR/STTR RPGS
Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac Arrest
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Columbia University Health Sciences United States 2021 – 2025

With advances in healthcare and effective public health campaigns, the survival rate after cardiac arrest (CA) has more than doubled during the last decade. However, as highlighte...

$7.76M
USD
Completed NON-SBIR/STTR RPGS
MIRA: The biological basis of paternal care in stickleback fish
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Illinois At Urbana-Champai... United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Parental care is critical to the health of both parents and offspring, yet little is known about how molecular substrates act within brain areas and neur...

$329.4K
USD
Completed NON-SBIR/STTR RPGS
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomes
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Sloan-Kettering Inst Can Research United States 2021 – 2024

ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for most forms of acute myelogenous leukemia (AML), but its 50% failure rate remains u...

$5.96M
USD
Completed NON-SBIR/STTR RPGS
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY.
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Wayne State University United States 2021 – 2024

ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY Despite serious pregnancy complications, 50% of women who use tobacco products will continue to do...

$3.88M
USD
Completed NON-SBIR/STTR RPGS
Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac Arrest
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Columbia University Health Sciences United States 2021 – 2025

With advances in healthcare and effective public health campaigns, the survival rate after cardiac arrest (CA) has more than doubled during the last decade. However, as highlighte...

$7.44M
USD
Completed NON-SBIR/STTR RPGS
MIRA: The biological basis of paternal care in stickleback fish
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES University of Illinois At Urbana-Champai... United States 2021 – 2025

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. The Abstract is unchanged. Parental care is c...

$3.86M
USD
Active NON-SBIR/STTR RPGS
Dissecting roles of microbiome-host interactions in colorectal neoplasia etiology using multi-omics data
NATIONAL CANCER INSTITUTE University of Virginia United States 2021 – 2026

PROJECT SUMMARY Microbiome dysbiosis has been increasingly recognized to be associated with colorectal neoplasia, including colorectal adenoma and colorectal cancer (CRC). Distur...

$2.49M
USD
Completed NON-SBIR/STTR RPGS
ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY.
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Wayne State University United States 2021 – 2025

ELECTRONIC CIGARETTE VAPING & VASCULAR SEQUELAE IN THE UTERUS DURING PREGNANCY Despite serious pregnancy complications, 50% of women who use tobacco products will continue to do...

$3.46M
USD