Browse All Grants
99,167 grants found
Showing 97,541 – 97,560 of 99,167 grants
Investigating multifactorial beta-catenin activation in hepatocellular cancers
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and lacks molecular- targeted therapies. Activation of Wnt/β-catenin cascade has be...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a canc...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies t...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension. PA is associated with cardiovascular morbidity and m...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies t...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a canc...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension. PA is associated with cardiovascular morbidity and m...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME ha...
The Role of PHF6 in HSC self-renewal and myeloid expansion
Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal....
Live Imaging of Immunity to M. tuberculosis
Project Summary Tuberculosis (TB), caused by the bacterium, Mycobacterium tuberculosis, kills more humans every year than does any other infectious disease, including HIV. Among th...
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue en...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME has...
Neural control of pancreatic endocrine function in obesity and diabetes
Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity. We will create a detailed and systemic view of defined pancreatic nerves,...
Immune response to inhalation of live attenuated vaccine in an outbred tularemia model (Resubmission)
Tularemia is a severe zoonotic disease in humans with fatality rates exceeding 30% in untreated subjects. Francisella tularensis, the causative organism, is a gram-negative coccoba...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME ha...
The Role of PHF6 in HSC self-renewal and myeloid expansion
Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal...
The Role of PHF6 in HSC self-renewal and myeloid expansion
Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal...
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue...