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99,167 grants found
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Adaptation and optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings
ABSTRACT African adolescent girls and young women (AGYW) face high rates of HIV and common mental disorders. HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevent...
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance PROJECT SUMMARY Vaccines face tougher safety standards than most pharmaceu...
Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries
Project Summary More than half a million patients, including children, have benefitted from the remarkable technological breakthrough that are cochlear implants (CI). An increasi...
Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects
PROJECT SUMMARY The unifying theme of this proposal is the aim to use state-of-the-art technologies to investigate the basic biology of mammalian organ development and human stru...
CORE A - Administrative Core
PROJECT SUMMARY The Administrative Core will coordinate the administrative, fiscal, and organization aspects of our PPG program. Personnel in this Core will facilitate scientific...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the ?-globin gene, resulting in altered red...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The di...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The di...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies.
Summary - A fundamental theme in personalized cancer medicine is to identify specific subgroups of patients, based on molecular biomarkers and/or tumor signatures, which will subs...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The di...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The di...
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart
Project Summary/Abstract Loss of cardiomyocytes by apoptosis and/or necrosis is a hallmark of cardiac ischemic injury, pathological remodeling, and end-stage heart failure. Althoug...
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
Heart failure (HF) is the most common reason for hospitalization and death among those older than 65 years, and statistic is projected to grow as our population ages. The socioecon...
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive. The rapid nature of type 2 diabetes mellitus (T...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
Excess glucocorticoids contribute to the development of diabetes and metabolic syndrome, which includes: obesity, hyperglycemia, hypercholesterolemia, insulin resistance, and liver...