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99,167 grants found
Showing 97,421 – 97,440 of 99,167 grants
RNA tools for probing spliceosome dynamics
Project Summary/Abstract Alternative splicing is a central mechanism to diversify genetic information on the post-transcriptional level. Advances in sequencing technologies reve...
Altering Cardiac Cell Fate for Heart Repair
Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive...
Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes
The proposed research plan will develop innovative bioconjugation and DNA-mediated cell assembly strategies for rapid creation of self-assembled multicellular scaffolds with progr...
Rational translation of gold nanoparticle mediated radiosensitization tothe clinic
The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (G...
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range...
RUNX:CBFb complex constrains fetal-restricted innate T cell generation from adult lymphopoietic progenitors
Summary During intrauterine development the immune system generates cell subsets that will colonize mucosal barriers. This process is restricted to a fetal/neonatal window as adu...
Damage-Associated Molecular Patterns Driving Fibrosis Progression in Scleroderma
June 3 2018 ABSTRACT Synchronous fibrosis in multiple organs is the defining hallmark of systemic sclerosis (SSc), but its pathogenesis remains poorly understood, and there is a...
Altering Cardiac Cell Fate for Heart Repair
Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive...
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range...
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range o...
RUNX:CBFb complex constrains fetal-restricted innate T cell generation from adult lymphopoietic progenitors
Summary During intrauterine development the immune system generates cell subsets that will colonize mucosal barriers. This process is restricted to a fetal/neonatal window as adult...
RNA tools for probing spliceosome dynamics
Project Summary/Abstract Alternative splicing is a central mechanism to diversify genetic information on the post-transcriptional level. Advances in sequencing technologies reveal...
Damage-Associated Molecular Patterns Driving Fibrosis Progression in Scleroderma
June 3 2018 ABSTRACT Synchronous fibrosis in multiple organs is the defining hallmark of systemic sclerosis (SSc), but its pathogenesis remains poorly understood, and there is an u...
Inflammation, Social Networks, and Depression in Rural Uganda
PROJECT SUMMARY Major depressive disorder is one of the top 5 contributors to years lived with disability among adults in sub- Saharan Africa. Numerous studies have suggested a l...
RNA tools for probing spliceosome dynamics
Project Summary/Abstract Alternative splicing is a central mechanism to diversify genetic information on the post-transcriptional level. Advances in sequencing technologies reve...
mHealth Facilitated Intervention to Improve Medication Adherence among Persons Living with HIV
There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable vira...
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range...
Altering Cardiac Cell Fate for Heart Repair
Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive f...
Damage-Associated Molecular Patterns Driving Fibrosis Progression in Scleroderma
June 3 2018 ABSTRACT Synchronous fibrosis in multiple organs is the defining hallmark of systemic sclerosis (SSc), but its pathogenesis remains poorly understood, and there is a...
Rational translation of gold nanoparticle mediated radiosensitization to the clinic
The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (G...