Browse All Grants
99,167 grants found
Showing 97,401 – 97,420 of 99,167 grants
Impairment of ischemia-induced vascular functions by PS1 FAD mutants
Cerebral microvasculature abnormalities, such as degeneration of the capillary endothelium, are implicated in the genesis of Alzheimer's disease (AD) neuropathology. In addition,...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significan...
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogene...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also i...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Leveraging platelet contraction cytometry for immune thrombocytopenia
PROJECT SUMMARY/ABSTRACT Defined by low platelet count in the absence of any other cause, immune thrombocytopenic purpura (ITP) affects over 4,000 US children and 8,000 adults ea...
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
PROJECT SUMMARY/ABSTRACT Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible blindness. The only current method to delay its d...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer,...
Near-IR Ratiometric Fluorescence Probes for Assessing Cargo Delivery to Prostate Tumors
PROJECT SUMMARY/ABSTRACT Prostate-specific membrane antigen (PSMA) is the hallmark enzyme-biomarker for prostate cancer because it is expressed in the epithelium of nearly all pro...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. A...
Near-IR Ratiometric Fluorescence Probes for Assessing Cargo Delivery to Prostate Tumors
PROJECT SUMMARY/ABSTRACT Prostate-specific membrane antigen (PSMA) is the hallmark enzyme-biomarker for prostate cancer because it is expressed in the epithelium of nearly all p...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy....
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy....
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy....
Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes
The proposed research plan will develop innovative bioconjugation and DNA-mediated cell assembly strategies for rapid creation of self-assembled multicellular scaffolds with progra...
Rational translation of gold nanoparticle mediated radiosensitization tothe clinic
The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (GN...
Inflammation, Social Networks, and Depression in Rural Uganda
PROJECT SUMMARY Major depressive disorder is one of the top 5 contributors to years lived with disability among adults in sub- Saharan Africa. Numerous studies have suggested a lin...
mHealth Facilitated Intervention to Improve Medication Adherence among Persons Living with HIV
There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable viral...
Inflammation, Social Networks, and Depression in Rural Uganda
PROJECT SUMMARY Major depressive disorder is one of the top 5 contributors to years lived with disability among adults in sub- Saharan Africa. Numerous studies have suggested a l...
mHealth Facilitated Intervention to Improve Medication Adherence among Persons Living with HIV
There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable vira...