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99,167 grants found
Showing 97,381 – 97,400 of 99,167 grants
A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptoms
PROJECT SUMMARY The Maternal, Infant, and Early Childhood Home Visiting Program is a national child abuse prevention strategy that serves vulnerable families throughout the Unit...
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Abstract Total pancreatectomy with islet autotransplant (TPIAT) is performed to treat the severe, intractable pain of chronic pancreatitis for patients who have failed medical or...
Defining the cell and molecular basis of Toxoplasma recrudescence
Project Summary Reactivation of toxoplasmosis is a significant health threat to people chronically infected with this parasite and is life-threatening to infected individuals tha...
Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing Gut
PROJECT SUMMARY/ABSTRACT This proposal will test the hypothesis that SOX transcription factors (TFs) modulate the genomic specificity of Wnt/Beta-catenin (BCAT) mediated transcri...
Application of Advanced Quantitative Methods to Schizophrenia Research
PROJECT SUMMARY Abnormalities of white matter are important in schizophrenia. A preponderance of studies have found decreased levels of transcripts for myelin-related proteins i...
Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's Disease
Abstract Alzheimer's Disease (AD) affects over 5 million Americans posing a significant burden to the community and health care system. Machine learning (ML) methods have been cr...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE 4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by the...
Role of ROCK isoform-mediated actin cytoskeleton modification in the pathogenesis of heart disease
PROJECT ABSTRACT The prevention and treatment of heart disease remain challenging. Rho kinase (also named ROCK) has recently emerged as a potential therapeutic target for variou...
Proteolytic regulation of the Streptococcus pyogenes cell surface
PROJECT SUMMARY/ABSTRACT Streptococcus pyogenes (Spy; group A Streptococcus) is the most prolific pathogen in the number of distinct diseases it is responsible for. Most commonly...
Stem Cell Surface Modification to Promote Nerve Regeneration
Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function and impaired quality of life for the patient. Stem...
Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases
PROJECT SUMMARY Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic disease characterized by lipid retention and vascular inflammation. Endothelial cel...
Adaptive optical microscopy for high-accuracy recording of neural activity in vivo
PROJECT SUMMARY To understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy, which requires methodologies with high spatial a...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African...
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers – both comprised, in large part, o...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory c...
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug target...
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
Protein S (PS) is a unique protein because it functions non-enzymatically as an anticoagulant, and because it interacts with plasma components that function in both hemostasis and...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD...
Inhibition of Radiation-Induced Coronary Microvascular Disease
ABSTRACT This application is designed to address the scientific goals of FOA-PA-19-112. Coronary microvascular disease (CMD) is major sequelae of chest radiotherapy in cancer su...