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99,167 grants found
Showing 97,321 – 97,340 of 99,167 grants
Personalized Dietary Management in Type 2 Diabetes
Abstract Hyperglycemia in type 2 diabetes (T2D) is associated with a variety of vascular complications of the disease, but clinical trials of medication regimens designed to achi...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plastic...
Proteolytic regulation of the Streptococcus pyogenes cell surface
PROJECT SUMMARY/ABSTRACT Streptococcus pyogenes (Spy; group A Streptococcus) is the most prolific pathogen in the number of distinct diseases it is responsible for. Most commonly...
Defining the cell and molecular basis of Toxoplasma recrudescence
Project Summary Reactivation of toxoplasmosis is a significant health threat to people chronically infected with this parasite and is life-threatening to infected individuals tha...
Immunity against fungal infections
PROJECT SUMMARY Despite the global rise in fungal infections, including those by endemic sp ., there is no licensed fungal vaccine available. This is mainly due to poor underst...
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
Clostridioides difficile is a spore-forming bacterial pathogen that is the leading cause of healthcare-associated infections in the United States. While C. difficile’s ability to...
Proteolytic regulation of the Streptococcus pyogenes cell surface
PROJECT SUMMARY/ABSTRACT Streptococcus pyogenes (Spy; group A Streptococcus) is the most prolific pathogen in the number of distinct diseases it is responsible for. Most commonly...
Immunity against fungal infections
PROJECT SUMMARY Despite the global rise in fungal infections, including those by endemic sp ., there is no licensed fungal vaccine available. This is mainly due to poor underst...
Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing Gut
PROJECT SUMMARY/ABSTRACT This proposal will test the hypothesis that SOX transcription factors (TFs) modulate the genomic specificity of Wnt/Beta-catenin (BCAT) mediated transcri...
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
PROJECT SUMMARY/ABSTRACT Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible blindness. The only current method to delay its d...
Impairment of Ischemia-induced Vascular Functions by PS1 FAD Mutants
Cerebral microvasculature abnormalities, such as degeneration of the capillary endothelium, are implicated in the genesis of Alzheimer's disease (AD) neuropathology. In addition,...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5 years. We submit a significantly revised pr...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory c...
Localizing and modulating competing memories of fear and safety in the human brain
PROJECT SUMMARY. Pathologies characterized by excessive fear and anxiety are the most common mental illness with a 12-month prevalence estimate of about 40 million American adults...
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers – both comprised, in large part, o...
Inhibition of Radiation-Induced Coronary Microvascular Disease
ABSTRACT This application is designed to address the scientific goals of FOA-PA-19-112. Coronary microvascular disease (CMD) is major sequelae of chest radiotherapy in cancer su...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH
PROJECT SUMMARY/ABSTRACT We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world. Menopausal symptoms including hot flushes...
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System
Project Summary/Abstract Intestinal motility is regulated by the Enteric Nervous System (ENS), which resides entirely within the gut wall and comprises the largest collection of...