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99,167 grants found
Showing 97,281 – 97,300 of 99,167 grants
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer?s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogenesi...
Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's Disease
Abstract Alzheimer's Disease (AD) affects over 5 million Americans posing a significant burden to the community and health care system. Machine learning (ML) methods have been cr...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summary: W...
Prefrontal ensemble dynamics during response execution and inhibition
PROJECT SUMMARY/ABSTRACT The balance between response execution and response inhibition (i.e., going vs. not-going or stopping) plays a fundamental role in regulating normal behavi...
Longitudinal Measurement of Neurodegeneration in two Murine Models of Multiple Sclerosis: A Clinical and Histopathologic Validation Study
PROJECT SUMMARY Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system whereby relentless demyelination and neuroaxonal loss are th...
Role of ROCK isoform-mediated actin cytoskeleton modification in the pathogenesis of heart disease
PROJECT ABSTRACT The prevention and treatment of heart disease remain challenging. Rho kinase (also named ROCK) has recently emerged as a potential therapeutic target for variou...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cel...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via imm...
Stem Cell Surface Modification to Promote Nerve Regeneration
Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function and impaired quality of life for the patient. Stem c...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plasticit...
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
Protein S (PS) is a unique protein because it functions non-enzymatically as an anticoagulant, and because it interacts with plasma components that function in both hemostasis and...
Leveraging platelet contraction cytometry for immune thrombocytopenia
PROJECT SUMMARY/ABSTRACT Defined by low platelet count in the absence of any other cause, immune thrombocytopenic purpura (ITP) affects over 4,000 US children and 8,000 adults ea...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world. Menopausal symptoms including hot flushes...
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers – both comprised, in large part, o...
Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH
PROJECT SUMMARY/ABSTRACT We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care co...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD h...
Defining the cell and molecular basis of Toxoplasma recrudescence
Project Summary Reactivation of toxoplasmosis is a significant health threat to people chronically infected with this parasite and is life-threatening to infected individuals that...
Proteolytic regulation of the Streptococcus pyogenes cell surface
PROJECT SUMMARY/ABSTRACT Streptococcus pyogenes (Spy; group A Streptococcus) is the most prolific pathogen in the number of distinct diseases it is responsible for. Most commonly S...
Immunity against fungal infections
PROJECT SUMMARY Despite the global rise in fungal infections, including those by endemic sp ., there is no licensed fungal vaccine available. This is mainly due to poor understandi...