Browse All Grants
99,167 grants found
Showing 97,261 – 97,280 of 99,167 grants
Characterizing upstream regulators of glucosylceramide metabolism for Parkinson's disease and Lewy Body Dementia
Parkinson?s disease (PD)-associated dementia and Lewy Body Dementia (LBD) incidence is high among the aged population with 1% of those over 60 and 4% of those over 80. Mutations in...
Mesodermal Commitment of the Definitive Hematopoietic Program
PROJECT SUMMARY / ABSTRACT The overall goal of our research is to understand the origin, development and regulation of the embryonic progenitor to the hematopoietic stem cell (HSC)...
Formyl peptide receptor activation induces vascular plasticity and remodeling in hypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown th...
Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.
Abstract Cells sense the extracellular environment primarily using G protein-coupled receptors (GPCRs). They represent the largest family of cell surface proteins and play key phy...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Development of Novel Metal-Based Supramolecular Therapeutics for Ovarian Cancer
PROJECT SUMMARY Our goal in this R15 proposal is to engineer novel photoactivatable Pt(IV) metallodrugs for ovarian cancer therapy. Platinum-based metallodrugs are widely used in...
Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing Gut
PROJECT SUMMARY/ABSTRACT This proposal will test the hypothesis that SOX transcription factors (TFs) modulate the genomic specificity of Wnt/Beta-catenin (BCAT) mediated transcript...
Deciphering the tau phosphorylation code
Alzheimer?s disease (AD) is a neurodegenerative disorder characterized by plaques comprised of A?, and neurofibrillary tangles (NFTs) containing the microtubule associated protein...
Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's Disease
Abstract Alzheimer's Disease (AD) affects over 5 million Americans posing a significant burden to the community and health care system. Machine learning (ML) methods have been cruc...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...
Developing a clinical and research framework for evaluating inflammation pathway dysregulation in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) is the most common cause of dementia worldwide. In the US, it is the fifth leading cause of death in people over 65 years of age...
Toward precision medicine: modulation of ABCA7 associated risk of Alzheimer's disease by ancestry
Abstract Ethnic and cultural diversity offers economic and societal benefits. It also poses challenges in therapeutic development and health care provision. However, ancestry has...
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System
Project Summary/Abstract Intestinal motility is regulated by the Enteric Nervous System (ENS), which resides entirely within the gut wall and comprises the largest collection of...
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers ? both comprised, in large part, of...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via neuropathometry of dissection photos with 3D scanning Summary: While mo...
Post-acute Care Outcomes of Patients with Alzheimer's Disease and Related Dementias: the Role of Skilled Nursing Facility Specialists
PROJECT SUMMARY Over 1.1 million patients admitted annually to skilled nursing facilities (SNFs) for post-acute care after a hospitalization have Alzheimer?s Disease or Related Dem...
Single molecule kinetic studies of gamma-secretase/substrate interaction and the effects of AD-causing mutations
Project Summary Amyloid plaque, composed of amyloid-b peptide (Ab), is a pathological hallmark of Alzheimer?s disease (AD). g-secretase is responsible for the cleavage of C99, the...
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Project Summary The aggregate failure of pre-clinical and clinical trials in AD has demonstrated that an improved fundamental understanding of memory and how the molecular componen...
The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People with Dementia
PROJECT SUMMARY Antipsychotics are frequently prescribed to older adults with Alzheimer?s disease and related dementias (ADRD) to treat behavioral symptoms, but clinical guidelines...
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
ABSTRACT Traumatic brain injury (TBI) is significantly correlated with increased risk for developing several neurodegenerative disorders, including Alzheimer?s Disease (AD) and AD-...