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Abstract of Parent U01 AG071450 Alzheimer’s Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer's Disease
PROJECT SUMMARY/ABSTRACT The CYCLE-AD (Cycling to Cease or Limit the Effects of Alzheimer’s Disease) is a randomized controlled trial (RCT) that was funded on January 15, 2021, f...
Measurement in Health: Advancing Assessment of Delirium
Delirium, an acute clinical syndrome characterized by inattention and cognitive disturbances, is a common, preventable, and costly problem for older persons. Over 3 million people...
Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training
Many investigators have attempted to show that using intensive cognitive training to increase Attention- Deficit/Hyperactivity Disorder (ADHD) patients? capacity to store informati...
Identifying best methods for the detection of subtle cognitive decline
PROJECT SUMMARY / ABSTRACT New submission for PAS-19-391 (Small Research Grant Program for the Next Generation of Researchers in AD/ADRD Research: Area of Focus Archiving and Lever...
Humanization of a Notch 3 agonist antibody for pre-clinical development of a CADASIL treatment
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease char...
Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging
Project Summary Many of the major biological discoveries of the 20th century were made using very few model species. They were chosen for historical tractability, rather than biolo...
Adult-Daughter Caregivers Pursuit of Personal Physical Activity Goals: The ACHIEVE Study
PROJECT SUMMARY/ABSTRACT As the United States population grows increasingly older, millions of U.S. women find themselves providing care for older parents with Alzheimer?s disease...
Developing a clinical and research framework for evaluating inflammation pathway dysregulation in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) is the most common cause of dementia worldwide. In the US, it is the fifth leading cause of death in people over 65 years of age....
Development of isogenic iPSC cell lines expressing tauopathy-related PERK risk variants to study homeostatic control of protein levels during ER stress
Project Summary In neurodegenerative diseases, accumulation of misfolded proteins is the pathological hallmark. Levels of the toxic proteins, such as tau, correspond to cellular dy...
A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptoms
PROJECT SUMMARY The Maternal, Infant, and Early Childhood Home Visiting Program is a national child abuse prevention strategy that serves vulnerable families throughout the United...
New Survey Measures of Mortality at Older Ages in Low and Middle-Income Countries
PROJECT SUMMARY Following large declines in childhood mortality and progress in lowering mortality from causes of death that affect young adults, mortality is rapidly shifting to a...
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkers
One major clinical challenge for diagnosis of recurrent glioblastoma (GBM) is assessment of response to treatment. While standard chemo-radiotherapy improves survival, it also comp...
Define molecular events driving selective neuronal death in multiple neurodegenerative diseases by snRNA-seq
Project Summary Despite decades of research, currently the mechanisms of neurodegeneration in Alzheimer?s disease (AD) and Parkinson Disease (PD) remain controversial and there are...
Transcriptomic and epigenomic landscape of neurodegenerative disease models
Project Summary This proposal seeks to characterize the transcriptome and epigenome of genetic models of Alzheimer's disease (AD) in Drosophila melanogaster. We will use a computat...
Investigation of the role of glia cells in Alzheimers pathogenesis in a functional human-based in vitro model
Scientific Abstract / Summary Alzheimer?s disease (AD) is the most prevalent neurodegenerative disorder characterized by progressive cognitive decline that leads to age-related dem...
Toward precision medicine: modulation of ABCA7 associated risk of Alzheimer's disease by ancestry
Abstract Ethnic and cultural diversity offers economic and societal benefits. It also poses challenges in therapeutic development and health care provision. However, ancestry has n...
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
PROJECT SUMMARY The high rate of recurrence and treatment-related mortalities in pediatric acute myeloid leukemia (AML) under- scores the critical need to develop targeted therapie...
Developing a screening platform to identify inhibitors of pathological self-assembly of Tau
Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disorder that currently affects an estimated 5.7 million individuals in the USA. This age onset disord...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE ?4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by the W...