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99,167 grants found
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Senescence of Pre-Osteoclasts in Non-Traumatic OA
SUMMARY/ABSTRACT Osteoarthritis (OA) is the most prevalent age-associated chronic joint disease. Although direct joint injury and excessive mechanical overloading are considered...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing...
Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device
Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain i...
ENIGMA World Aging Center
ABSTRACT One in three seniors dies with Alzheimer’s disease (AD) or another dementia - diseases that cost the nation $259 billion, to rise to $1.1 trillion by 2050 (Alzheimer’s A...
Synergistic microglial activation and tumor cell killing for improved GBM response
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Current therapies remain unsuccessful in improving overall survival;...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death amon...
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer's Disease and other disorders (ADRDs) is now a public health crisis. In the absence of effective medical treatment, there is a critical need for behavi...
Post-acute Care Outcomes of Patients with Alzheimer's Disease and Related Dementias: the Role of Skilled Nursing Facility Specialists
PROJECT SUMMARY Over 1.1 million patients admitted annually to skilled nursing facilities (SNFs) for post-acute care after a hospitalization have Alzheimer’s Disease or Related D...
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
Protein S (PS) is a unique protein because it functions non-enzymatically as an anticoagulant, and because it interacts with plasma components that function in both hemostasis and...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death amon...
Post-acute Care Outcomes of Patients with Alzheimer's Disease and Related Dementias: the Role of Skilled Nursing Facility Specialists
PROJECT SUMMARY Over 1.1 million patients admitted annually to skilled nursing facilities (SNFs) for post-acute care after a hospitalization have Alzheimer’s Disease or Related D...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African...
Synergistic microglial activation and tumor cell killing for improved GBM response
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Current therapies remain unsuccessful in improving overall survival;...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer,...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer,...
Hearing Assessment Supplement for Wave VI of Add Health
Abstract of Parent U01 AG071450 Alzheimer’s Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death amon...
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer’s Disease and other disorders (ADRDs) represents a public health crisis. In the absence of effective medical treatment, there is a critical need for be...