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99,167 grants found
Showing 97,181 – 97,200 of 99,167 grants
Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device
Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain i...
Application of Advanced Quantitative Methods to Schizophrenia Research
PROJECT SUMMARY Abnormalities of white matter are important in schizophrenia. A preponderance of studies have found decreased levels of transcripts for myelin-related proteins i...
Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases
PROJECT SUMMARY Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic disease characterized by lipid retention and vascular inflammation. Endothelial cel...
Prefrontal ensemble dynamics during response execution and inhibition
PROJECT SUMMARY/ABSTRACT The balance between response execution and response inhibition (i.e., going vs. not-going or stopping) plays a fundamental role in regulating normal beha...
Localizing and modulating competing memories of fear and safety in the human brain
PROJECT SUMMARY. Pathologies characterized by excessive fear and anxiety are the most common mental illness with a 12-month prevalence estimate of about 40 million American adults...
Inhibition of Radiation-Induced Coronary Microvascular Disease
ABSTRACT This application is designed to address the scientific goals of FOA-PA-19-112. Coronary microvascular disease (CMD) is major sequelae of chest radiotherapy in cancer su...
Personalized Dietary Management in Type 2 Diabetes
Abstract Hyperglycemia in type 2 diabetes (T2D) is associated with a variety of vascular complications of the disease, but clinical trials of medication regimens designed to achi...
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
PROJECT SUMMARY/ABSTRACT Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible blindness. The only current method to delay its d...
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
PROJECT SUMMARY The high rate of recurrence and treatment-related mortalities in pediatric acute myeloid leukemia (AML) under- scores the critical need to develop targeted therap...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death amon...
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkers
One major clinical challenge for diagnosis of recurrent glioblastoma (GBM) is assessment of response to treatment. While standard chemo-radiotherapy improves survival, it also com...
A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptoms
PROJECT SUMMARY The Maternal, Infant, and Early Childhood Home Visiting Program is a national child abuse prevention strategy that serves vulnerable families throughout the Unit...
Defining the cell and molecular basis of Toxoplasma recrudescence
Project Summary Reactivation of toxoplasmosis is a significant health threat to people chronically infected with this parasite and is life-threatening to infected individuals tha...
The impact of post acute care payment changes on access and outcomes
Project Summary/Abstract Substantial changes in Medicare payment policies are occurring for post-acute care (PAC), which provides a bridge from the hospital to home for individua...
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Abstract Total pancreatectomy with islet autotransplant (TPIAT) is performed to treat the severe, intractable pain of chronic pancreatitis for patients who have failed medical or...
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
ABSTRACT Traumatic brain injury (TBI) is significantly correlated with increased risk for developing several neurodegenerative disorders, including Alzheimer’s Disease (AD) and A...
Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device
Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain i...
Advanced machine learning algorithms that integrate multi-modal neuroimaging to quantify the heterogeneity in Alzheimer's Disease
Abstract Alzheimer's Disease (AD) affects over 5 million Americans posing a significant burden to the community and health care system. Machine learning (ML) methods have been cr...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE 4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by the...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summary: W...