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99,167 grants found
Showing 97,161 – 97,180 of 99,167 grants
Post-acute Care Outcomes of Patients with Alzheimer's Disease and Related Dementias: the Role of Skilled Nursing Facility Specialists
PROJECT SUMMARY Over 1.1 million patients admitted annually to skilled nursing facilities (SNFs) for post-acute care after a hospitalization have Alzheimer’s Disease or Related D...
Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training
Many investigators have attempted to show that using intensive cognitive training to increase Attention- Deficit/Hyperactivity Disorder (ADHD) patients’ capacity to store informat...
Longitudinal Measurement of Neurodegeneration in two Murine Models of Multiple Sclerosis: A Clinical and Histopathologic Validation Study
PROJECT SUMMARY Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system whereby relentless demyelination and neuroaxonal loss are...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of ADRD...
The impact of post acute care payment changes on access and outcomes
Project Summary/Abstract Substantial changes in Medicare payment policies are occurring for post-acute care (PAC), which provides a bridge from the hospital to home for individua...
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Abstract Total pancreatectomy with islet autotransplant (TPIAT) is performed to treat the severe, intractable pain of chronic pancreatitis for patients who have failed medical or...
Pediatric HIV/AIDS Cohort Study (PHACS) 2020
Project Summary/Abstract Each year, there are more than 1 million pregnant women living with HIV (PWLHIV) who receive antiretroviral medications (ARVs) for treatment and perinatal...
Training Promotoras/Community Health Workers using Culturally and Linguistically-Appropriate Research Best Practices
Project Summary Good clinical practice is essential training for the clinical research workforce that supports the integrity and rigor of clinical research during implementation. W...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogene...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via i...
Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training
Many investigators have attempted to show that using intensive cognitive training to increase Attention- Deficit/Hyperactivity Disorder (ADHD) patients’ capacity to store informat...
Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH
PROJECT SUMMARY/ABSTRACT We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care...
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
ABSTRACT Traumatic brain injury (TBI) is significantly correlated with increased risk for developing several neurodegenerative disorders, including Alzheimer’s Disease (AD) and A...
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT
Project Summary/Abstract Although HIV-infected patients in the western world have a life expectancy near that of the general population, they are at a significantly elevated risk...
Mesodermal Commitment of the Definitive Hematopoietic Program
PROJECT SUMMARY / ABSTRACT The overall goal of our research is to understand the origin, development and regulation of the embryonic progenitor to the hematopoietic stem cell (HS...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public hea...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plastic...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug target...