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Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer's Disease and other disorders (ADRDs) is now a public health crisis. In the absence of effective medical treatment, there is a critical need for behavi...
An ounce of prevention: stopping menopausal bone loss before it starts
Summary The aphorism “an ounce of prevention is worth a pound of cure” very much applies to postmenopausal osteoporosis. Immediately following menopause, bone loss rates can rea...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acr...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also i...
Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process. Skeletal degeneratio...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75 years), primarily through the elimination of lives lost due to prematur...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance collabo...
Endplate Sensory Innervations for LBP
ABSTRACT Persistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor...
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
SUMMARY Low back pain is the leading cause of disability, driven predominantly by aging. Pain contributes to frailty by lowering quality of life and limiting physical activities....
Senescence of Pre-Osteoclasts in Non-Traumatic OA
SUMMARY/ABSTRACT Osteoarthritis (OA) is the most prevalent age-associated chronic joint disease. Although direct joint injury and excessive mechanical overloading are considered...
Stem Cell Surface Modification to Promote Nerve Regeneration
Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function and impaired quality of life for the patient. Stem...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer,...
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias
PROJECT SUMMARY The overall objective of the proposed work is to understand factors mediating and moderating transfer of learning in the context of training Working Memory (WM) sys...
Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging
Project Summary Many of the major biological discoveries of the 20th century were made using very few model species. They were chosen for historical tractability, rather than bio...
Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH
PROJECT SUMMARY/ABSTRACT We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care...
Synergistic microglial activation and tumor cell killing for improved GBM response
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Current therapies remain unsuccessful in improving overall survival;...
Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.
Abstract Cells sense the extracellular environment primarily using G protein-coupled receptors (GPCRs). They represent the largest family of cell surface proteins and play key p...
Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults
OTHER PROJECT INFORMATION – Project Summary/Abstract Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults The rapid aging of the U.S. population, wi...
New Survey Measures of Mortality at Older Ages in Low and Middle-Income Countries
PROJECT SUMMARY Following large declines in childhood mortality and progress in lowering mortality from causes of death that affect young adults, mortality is rapidly shifting to...
The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People with Dementia
PROJECT SUMMARY Antipsychotics are frequently prescribed to older adults with Alzheimer’s disease and related dementias (ADRD) to treat behavioral symptoms, but clinical guidelin...