Browse All Grants
99,167 grants found
Showing 97,061 – 97,080 of 99,167 grants
Endogenous retrovirus analyses in myalgic encephalomyelitis
Project Summary/Abstract Myalgic encephalomyelitis (ME) is a disabling and complex disease with 1-2.5 million patients in the United States. ME patients have low quality of life...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an ?endocrine organ? and significantly contribute to metab...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non?coding (nc) transcriptome remains an under?explored landscape for functional genomics. Recently, ~2,000 long non?coding (lnc)RNAs were identified b...
A novel form of light chain gene replacement
PROJECT SUMMARY B and T lymphocytes form the foundation of our adaptive immune system, which is based on specific recognition of foreign molecules by structurally diverse surface a...
TNRSF13B polymorphisms and the control of innate B cell responses – a double edged sword
Abstract Enteric bacterial pathogens profoundly impact the health and development of children, especially in developing countries. We unexpectedly discovered that polymorphisms of...
Molecular basis of heme scavenging by Gram-positive bacteria
Project Summary Nearly all species of bacteria require iron to grow because it is an essential metal cofactor that is used by microbial enzymes to mediate cellular metabolism. Du...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an “endocrine organ” and significantly contribute to met...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified...
Molecular basis of heme scavenging by Gram-positive bacteria
Project Summary Nearly all species of bacteria require iron to grow because it is an essential metal cofactor that is used by microbial enzymes to mediate cellular metabolism. Du...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an “endocrine organ” and significantly contribute to met...
Driving Skills of Adolescents with Obstructive Sleep Apnea (OSA)
Project Summary Despite major public health efforts, auto crashes remain by far the leading cause of death among 16-19 year-olds and are a major cause of non-fatal injuries. There...
Intermittent hypoxia and hypertension: Role of the lamina terminalis
The central objective of this research program is to determine the role of the CNS in hypertension associated with chronic intermittent hypoxia (CIH), a model of hypoxemia associa...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tum...
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
ABSTRACT About 55% of children with significant mental health difficulties receive treatment and up to 80% of children with sub-clinical symptoms receive no treatment. Treatments...
High-resolution mapping of the human brainstem during continence and micturition: noninvasive in vivo 7 Tesla fMRI study
The lower urinary tract (LUT) – bladder, bladder neck, urethra, and urethral sphincter – is controlled by a complex neural network. A delicate and complex switch/relay exists betw...