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99,167 grants found
Showing 97,001 – 97,020 of 99,167 grants
Molecular basis for the regulation of IgE class switch recombination by IL-21 and STAT3
Project Summary/Abstract The incidence of allergic diseases has been steadily increasing in modernized societies and represents a major public health problem. One of the main trigg...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful v...
Dieldrin-induced differential gene methylation and parkinsonian toxicity
Project Summary The majority of Parkinson’s disease (PD) cases are not caused by an inherited monogenic mutation and disease etiology involves a combination of genetic and enviro...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and licen...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful...
Molecular basis for the regulation of IgE class switch recombination by IL-21 and STAT3
Project Summary/Abstract The incidence of allergic diseases has been steadily increasing in modernized societies and represents a major public health problem. One of the main tri...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and licen...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and licen...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is cha...
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal Fluid
Cilia are microtubule-based cellular protrusions with diverse biological functions, including fluid movement, cellular locomotion, environmental sensing, and signal transduction....
Cooperative roles of FHA and ACT in Bordetella virulence
Summary/Abstract Pertussis (aka whooping cough) is re-emerging in developed countries despite high vaccine coverage. Resurgence is due primarily to waning immunity to the causal...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is cha...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is cha...
Calcium Dysregulation and Cell Function in Spinal Muscular Atrophy
PROJECT SUMMARY/ABSTRACT Spinal muscular atrophy (SMA) is one of the most common inherited cause of death in infants and young children. SMA is caused by the deletion or mutation...
Role of African-centric TP53 variant in higher H. pylori prevalence in African Americans
Project Summary African Americans have a 6-fold higher H. pylori (Hp) infection than the non-Hispanic white population; however, underlying gene(s) for this disparity remain elus...