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99,167 grants found
Showing 96,981 – 97,000 of 99,167 grants
The Impact of Maternal CMV Infection on Birth Outcomes
Congenital Cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in the U.S., affecting thousands of children each year. Notably, the m...
Engineered ImmuneChip Platform to Study B cell Migration and Affinity Maturation
PROJECT SUMMARY Developing vaccines against emerging infections such as SARS-COV-2 and influenza requires an enhanced understanding of the underlying antibody immune response in th...
Pseudomonas aeruginosa heme sensing inhibitors targeting HasAp
PROJECT SUMMARY Multidrug-resistant (MDR) Pseudomonas aeruginosa (Pa) is responsible for ~10% of nosocomial infections, highlighting the critical need for the development of novel...
Role of caspase-8 in innate immunity to infection
PROJECT SUMMARY Although inflammatory responses play a key role in controlling infection, dysregulated inflammation is associated with inflammatory and immune-mediated diseases. IL...
The Impact of Maternal CMV Infection on Birth Outcomes
Congenital Cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in the U.S., affecting thousands of children each year. Notably, the m...
A Machine Learning-Based Clinical Decision Support Tool to Predict Abdominal Aortic Aneurysm Prognosis Using Existing Longitudinal Data
SUMMARY: A Machine Learning-Based Clinical Decision Support Tool to Predict AAA Prognosis Abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta. If left untreate...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle...
Epigenetic Determinants and Mechanisms Influencing Genital Chlamydia trachomatis Reinfection in African American Women
Summary/Abstract: Chlamydia trachomatis (Ct) infection is the most prevalent sexually transmitted bacterial infection in the world. In the US alone, an estimated 3 million chlamyd...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 geneti...
Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged Tick
PROJECT SUMMARY Microbial residents of arthropod disease vectors engender profound effects on the biology of their host, both positive (e.g., nutrient acquisition, defense from...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 geneti...
Role of caspase-8 in innate immunity to infection
PROJECT SUMMARY Although inflammatory responses play a key role in controlling infection, dysregulated inflammation is associated with inflammatory and immune-mediated diseases....
Pseudomonas aeruginosa heme sensing inhibitors targeting HasAp
PROJECT SUMMARY Multidrug-resistant (MDR) Pseudomonas aeruginosa (Pa) is responsible for ~10% of nosocomial infections, highlighting the critical need for the development of nove...
Engineered ImmuneChip Platform to Study B cell Migration and Affinity Maturation
PROJECT SUMMARY Developing vaccines against emerging infections such as SARS-COV-2 and influenza requires an enhanced understanding of the underlying antibody immune response in...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 geneti...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle...
Dieldrin-induced differential gene methylation and parkinsonian toxicity
Project Summary The majority of Parkinson?s disease (PD) cases are not caused by an inherited monogenic mutation and disease etiology involves a combination of genetic and environm...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and license...