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99,167 grants found
Showing 96,961 – 96,980 of 99,167 grants
FAST-FNA immune cell profiling in HNSCC
Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue. Cu...
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. Ho...
Schwann Cell Regulation of Hematopoiesis
Project Summary/Abstract: Physiologic blood cell production is regulated by peripheral nerve fibers that innervate the bone marrow. Aging, diabetes, neurotoxic drugs and certain my...
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics in...
Core Fucosylation of N-linked Glycans as a Regulator of CD8+ T cell Activation and Function
PROJECT SUMMARY/ABSTRACT Post-translational carbohydrate modifications are important mediators of several cellular processes including protein turnover, cell adhesion, signal trans...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION: It is truly remarkable that our bodies turn over on average about one million cells every second of life....
Schwann Cell Regulation of Hematopoiesis
Project Summary/Abstract: Physiologic blood cell production is regulated by peripheral nerve fibers that innervate the bone marrow. Aging, diabetes, neurotoxic drugs and certain...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION: It is truly remarkable that our bodies turn over on average about one million cells every second of life...
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics i...
Core Fucosylation of N-linked Glycans as a Regulator of CD8+ T cell Activation and Function
PROJECT SUMMARY/ABSTRACT Post-translational carbohydrate modifications are important mediators of several cellular processes including protein turnover, cell adhesion, signal tra...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION: It is truly remarkable that our bodies turn over on average about one million cells every second of life...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION: It is truly remarkable that our bodies turn over on average about one million cells every second of life...
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics i...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION: It is truly remarkable that our bodies turn over on average about one million cells every second of life...
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics i...
Epigenetic Determinants and Mechanisms Influencing Genital Chlamydia trachomatis Reinfection in African American Women
Summary/Abstract: Chlamydia trachomatis (Ct) infection is the most prevalent sexually transmitted bacterial infection in the world. In the US alone, an estimated 3 million chlamydi...
A Machine Learning-Based Clinical Decision Support Tool to Predict Abdominal Aortic Aneurysm Prognosis Using Existing Longitudinal Data
SUMMARY: A Machine Learning-Based Clinical Decision Support Tool to Predict AAA Prognosis Abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta. If left untreated...
Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged Tick
PROJECT SUMMARY Microbial residents of arthropod disease vectors engender profound effects on the biology of their host, both positive (e.g., nutrient acquisition, defense from pa...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle ch...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 genetic...