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Showing 96,94196,960 of 99,167 grants

Completed NON-SBIR/STTR RPGS
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM Wake Forest University Health Sciences United States 2021 – 2024

PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicat...

$2.49M
USD
Completed NON-SBIR/STTR RPGS
A rapid, automated system for bacteria profiling of intra-abdominal infections
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Maryland, College Park United States 2021 – 2025

Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate a...

$5.81M
USD
Completed NON-SBIR/STTR RPGS
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Miami School of Medicine United States 2021 – 2025

Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases. Recently, a new group of human genes was linked to obesity, the genes...

$4.67M
USD
Completed NON-SBIR/STTR RPGS
Cystitis-induced bladder dysfunction and pain
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Vermont & St Agric College United States 2021 – 2025

Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pa...

$4.66M
USD
Completed NON-SBIR/STTR RPGS
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Stanford University United States 2021 – 2025

Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cu...

$7.25M
USD
Completed NON-SBIR/STTR RPGS
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH D... University of Chicago United States 2021 – 2024

PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of...

$7.45M
USD
Completed NON-SBIR/STTR RPGS
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH D... University of Chicago United States 2021 – 2024

PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review o...

$7.19M
USD
Completed NON-SBIR/STTR RPGS
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH D... University of Chicago United States 2021 – 2024

PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review o...

$6.51M
USD
Completed NON-SBIR/STTR RPGS
Fluid shear stress mechanotransduction at endothelial cell-cell junctions
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Yale University United States 2021 – 2024

Summary of the funded parent grant The goal of our project “Fluid shear stress mechanotransduction at endothelial cell-cell junctions” is to elucidate mechanisms by which vascula...

$845.7K
USD
Completed NON-SBIR/STTR RPGS
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH D... University of Chicago United States 2021 – 2025

PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review o...

$5.52M
USD
Completed NON-SBIR/STTR RPGS
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Beth Israel Deaconess Medical Center United States 2021 – 2025

Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness,...

$4.53M
USD
Completed NON-SBIR/STTR RPGS
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of South Florida United States 2021 – 2024

Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. How...

$5.41M
USD
Completed NON-SBIR/STTR RPGS
FAST-FNA immune cell profiling in HNSCC
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2025

Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue. Cur...

$6.71M
USD
Completed NON-SBIR/STTR RPGS
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Beth Israel Deaconess Medical Center United States 2021 – 2025

Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness...

$4.34M
USD
Completed NON-SBIR/STTR RPGS
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of South Florida United States 2021 – 2024

Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. Ho...

$5.29M
USD
Completed NON-SBIR/STTR RPGS
FAST-FNA immune cell profiling in HNSCC
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2025

Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue. Cu...

$6.57M
USD
Completed NON-SBIR/STTR RPGS
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Beth Israel Deaconess Medical Center United States 2021 – 2025

Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness...

$4.34M
USD
Completed NON-SBIR/STTR RPGS
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of South Florida United States 2021 – 2024

Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. Ho...

$5.29M
USD
Completed NON-SBIR/STTR RPGS
FAST-FNA immune cell profiling in HNSCC
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2025

Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue. Cu...

$6.57M
USD
Completed NON-SBIR/STTR RPGS
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Beth Israel Deaconess Medical Center United States 2021 – 2025

Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness...

$4.34M
USD