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99,167 grants found
Showing 96,921 – 96,940 of 99,167 grants
Exploring the heterogeneity of the vaccine-elicited T cell response by scRNAseq
PROJECT SUMMARY Clinically relevant cellular responses to either experimental or FDA approved vaccine adjuvant formulations have been difficult to generate and/or detect. Given the...
Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) Cohort
PROJECT SUMMARY Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. AD is associated with defective skin barrier function, microb...
Data Management Core: Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity
PROJECT SUMMARY The overarching goal of the proposed Human Immunology Project Consortium (HIPC) is to characterize vaccine-induced biological variations (transcriptomic/proteomic;...
Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) Cohort
PROJECT SUMMARY Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. AD is associated with defective skin barrier function, microb...
Exploring the heterogeneity of the vaccine-elicited T cell response by scRNAseq
PROJECT SUMMARY Clinically relevant cellular responses to either experimental or FDA approved vaccine adjuvant formulations have been difficult to generate and/or detect. Given t...
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases. Recently, a new group of human genes was linked to obesity, the genes...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known a...
Cystitis-induced bladder dysfunction and pain
Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pa...
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cu...
SPMs, linoleic acid, and antibody levels in obesity
PROJECT SUMMARY Numerous studies have defined how obesity impairs chronic inflammation. In contrast, far less is known about how obesity impairs humoral immunity, which is respon...
A rapid, automated system for bacteria profiling of intra-abdominal infections
Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate a...
Contribution of c-Maf to regulatory B cells and antibody-secreting cells
PROJECT SUMMARY Regulatory B cells are involved in many pathophysiological processes, such as promoting tolerance in autoimmunity and organ transplantation, but also reducing imm...
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicat...
A rapid, automated system for bacteria profiling of intra-abdominal infections
Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate a...
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases. Recently, a new group of human genes was linked to obesity, the genes...
Cystitis-induced bladder dysfunction and pain
Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pa...
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cu...
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicat...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known a...
Delineating sex-specific abstinence-induced negative affective behavior in insular circuitry
Project Summary/Abstract Alcohol Use Disorder (AUD) is a growing problem in our nation and worldwide. The COVID-19 pandemic has led to a significant increase in alcohol use, with...