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99,167 grants found
Showing 96,901 – 96,920 of 99,167 grants
Maintenance of synapses during adulthood in Drosophila
PROJECT SUMMARY The goal of this proposal is to identify genes that regulate an age-dependent change in active zones (AZs) that causes an age-dependent decline in neuron function....
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of many...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of ma...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of ma...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Environmental genotoxin exposure is responsible for 80-90% of the risk of developing cancer. Indeed, Whole Genome Sequencing studies show that human cancers carry...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of ma...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known a...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY The proposed diversity supplement supports post-doctoral research training for Dr. Marimar Contreras-Nieves, MD, MS candidate. Dr. Contreras-Nieves aims to develo...
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicat...
Cystitis-induced bladder dysfunction and pain
Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pain...
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases. Recently, a new group of human genes was linked to obesity, the genes e...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known as...
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cul...
SPMs, linoleic acid, and antibody levels in obesity
PROJECT SUMMARY Numerous studies have defined how obesity impairs chronic inflammation. In contrast, far less is known about how obesity impairs humoral immunity, which is responsi...
Human anti-viral immune responses in tissues and circulation
Program Summary Studies of human immune responses to viruses and other pathogens have focused, by necessity, on sampling of peripheral blood; however, innate and adaptive immune re...
IMPACC convalescent data collection, including Patient Reported Outcomes (PROs) and home visit sampling
IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan...
Biomolecular Markers for Safe Minimization of Immunosuppression
We seek additional funds for research responsive to the SARS-CoV-2/COVID-19 outbreak that is in scope of our ongoing grant R37AI051652 ?Biomolecular Markers for Safe Minimization o...
A rapid, automated system for bacteria profiling of intra-abdominal infections
Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate ant...
Contribution of c-Maf to regulatory B cells and antibody-secreting cells
PROJECT SUMMARY Regulatory B cells are involved in many pathophysiological processes, such as promoting tolerance in autoimmunity and organ transplantation, but also reducing immun...