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99,167 grants found
Showing 96,861 – 96,880 of 99,167 grants
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality...
Methods For Evolutionary Genomics Analysis
Summary The parent R35 research program aims to develop innovative methods and tools for the comparative analysis of molecular sequences. The focus is on creating machine-learnin...
Molecular mechanisms of the mitochondrial permeability transition
Research Summary The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochond...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome durin...
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by an obliterative vasculopathy involving distal pulmonary...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conducta...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycos...
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A. Fisher developed much of the mathematical and conceptual framework underlying the stud...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis. Most of our understanding of the mechanisms that control the transcript...
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
Project Summary: Salt-sensitive hypertension is an independent predictor of death due to cardiovascular disease (CVD), but the mechanisms are poorly understood. Most of the researc...
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments. We and others have observed up to 15% of all DMGs to...
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
Branch vein occlusion (BVO) and diabetic retinopathy (DR) are major causes of new onset blindness in the US. These vascular disorders result in acellular capillaries secondary to i...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Elucidating the role of NK cells in Lewy body diseases
PROJECT SUMMARY/ABSTRACT Lewy body diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy are characterized by the accumulation of aggre...
Optical analogs to MRI contrast agents for surgical guidance of brain tumor resection
ABSTRACT Surgical resection is a fixture in the treatment of intracranial tumors, and there is mounting data indicating that overall and progression-free survival improve for gross...
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions. Organisma...
Function of RUNX1 in diverse Down syndrome tissues
Summary We seek to decipher the contribution of RUNX1 to the phenotypes seen in individuals with Down syndrome. RUNX1 is a chromosome 21 encoded transcription factor involved in b...
A hybrid effectiveness-implementation trial of a school based executive function treatment for transition age youth with autism
PROJECT SUMMARY The proposed study is highly relevant to the 2017 Interagency Autism Coordinating Committee priorities to improve transition to adulthood in autism spectrum disorde...
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...