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99,167 grants found
Showing 96,841 – 96,860 of 99,167 grants
Language Development and Social Interaction in Children with Hearing Loss
Project SummaryThis project uses objectively measured, longitudinal data to capture the vocal interactions of children with hearing loss in order to understand everyday factors tha...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
NCI Diversity Supplement: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
ABSTRACT A separate Abstract is not requested. This is an NCI Diversity Supplement to Dr. Juan Fueyo-Margareto’s NCI grant, R01 CA256006, titled, “Glioma therapy with oncolytic ade...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Evolutionary adaptation and spatial organization of signaling in the Mitotic Exit Network
Project Summary Sensing and processing information through signaling cascades is an essential part of cellular life. A few signaling cascades such as the MAP kinase and Hippo pathw...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Molecular mechanisms of the mitochondrial permeability transition
The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochondrial inner membrane...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Ethnoracial Impact on Blood-Based Biomarker Detection of Alzheimer's in Primary Care Patients
Project Summary/Abstract If no preventative measures are developed, the number of individuals suffering from Alzheimer’s Disease (AD) is expected to triple by 2050; many of whom wi...
MIRA supplement
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
Electroencephalographic biomarkers of response to vibroacoustically-augmented breath-focused mindfulness
Dissociation is a transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It occurs in the context of many trauma and stress-related disor...
Sex differences in cholinergic regulation of nicotinic acetylcholine receptor modulation of local nucleus accumbens circuitry underlying motivation
Project Summary/Abstract Candidate: My long term goal is to become an independent investigator running an interdisciplinary and collaborative research team to understand the mechan...
Impact of Loss-of-function NADPH Oxidase Variants on B-Cell Activation in SLE
PROJECT ABSTRACT Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE). However, despite these ins...
Characterizing the content of bilingual language in preschoolers with HL
Project Summary This Administrative Supplement will support post-baccalaureate researcher, Gabriela Gutierrez, to receive research training through her mentored leadership of a pro...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Fluorescent nucleosides, nucleotides and oligonucleotides
PROJECT SUMMARY Nucleic acids and their building blocks play central roles in all cellular events and, as such, have immense impact on the emergence of diseases and, in turn, on hu...