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99,167 grants found
Showing 96,801 – 96,820 of 99,167 grants
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may...
Optical nanosensor for 3D force sensing in intact tissues of live animals
PROJECT SUMMARY Physical forces are known to impact cell functions in a fundamental way. While the study dates back some 100-years, the scientific interests have significantly incr...
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry
ABSTRACT Alzheimer disease (AD) is the leading cause of dementia in older adults and occurs in all ethnic and racial groups. Genetic studies of AD have mostly been performed in non...
Diversification of cell types in the Drosophila retina - Resubmission - 1
Summary The development of a complex organ such as the eye involves the specification of multiple distinct cell types and the integration of their functions.In Drosophila, the ligh...
A Novel Approach to Restore Sight after Corneal Chemical Injury
Abstract Chemical burns to the eye are potentially blinding ocular injuries and constitute an ocular emergency requiring immediate assessment and initiation of treatment. They also...
Slow cycling cell RNA based T cell therapy to prevent recurrence in GBM
PROJECT SUMMARY AND ABSTRACT Conventional cancer treatments target fast-cycling cells, however slowly dividing populations tend to be spared recapitulating the tumor via their self...
Engineered Biomaterial for Endoscopic Treatment of Airway Fibrosis
PROJECT SUMMARY In this proposal, our primary goal is to explore the optimization of a biomaterial to prevent the recurrence of fibrosis and promote regeneration of mucosal epithel...
Sequence-universal high-frequency prospective MRI motion correction with navigators
Project Summary/Abstract Motion during magnetic resonance imaging (MRI) is estimated to cost hospitals approximately $115,000 per scanner per year, which implies that the annual co...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Blood-brain-barrier and white matter mechanisms underlying dementia
Abstract White matter (WM) damage has increasingly been recognized as an important contributing factor to neurodegeneration and dementia, however, little is known of the specific m...
Mitochondria targeting for Alzheimer's Disease
PROJECT SUMMARY OF PARENT AWARD Decreased energy metabolism is an invariant feature of the brains of Alzheimer's disease (AD) patients, yet the specific use of pharmacologic s...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra- thermodynamic catalysis and fluorine sculpting.The realizati...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary/Abstract: This equipment supplement project proposal seeks funds to purchase a Cold-Spray Ionization Mass Spectrometer to carry out CSI-MS experiments, a powerful a...
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary PI: Yuk-Ching Tse-Dinh This equipment supplement application requests funds to purchase an AKTA FPLC protein purification system for the large scale purification of...
Re-engagement at Discharge (Re-Charge): Improving post-hospital outcomes for HIV-infected adults in Zambia
PROJECT SUMMARY In sub-Saharan African countries, HIV-infected patients suffer high rates of loss-to-follow-up and mortality following hospital admission.Among HIV-infected patient...
Monitoring rapid guanosine signaling during ischemia
PROJECT SUMMARY Measuring dynamic guanosine signaling at the site of focal ischemia over time remains challenging to probe with existing technology yet knowledge of the dynamics, r...