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99,167 grants found
Showing 96,781 – 96,800 of 99,167 grants
Visual Form Perception Produced by Electrically Stimulating Human Visual Cortex
Project Summary/Abstract Blindness disables millions of people across the world. In most cases, incurable blindness is caused by damage or dysfunction of the eye, retina, or optic...
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in traumatized people with posttra...
TMS effects on circuit plasticity and drug seeking in mice.
Project Summary/Abstract Drug addiction is a leading cause of morbidity and mortality in the US. Opioid addiction in particular has become an epidemic with unprecedented overdose f...
Efficient estimation of auditory sensitivity and cognitive status using spoken-digit tests.
Project Summary/Abstract. Untreated age-related hearing loss (ARHL) is the most prevalent cause of reduced quality of life for persons 55 and older in the US. There are 30+ million...
Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease
PROJECT SUMMARY Subthalamic deep brain stimulation (DBS) can significantly improve the motor symptoms and quality of life of patients with Parkinson’s disease (PD). Recent advances...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
ABSTRACT Recently there has been compelling evidence that inflammatory bowel disease (IBD) subjects, both Crohn's disease (CD) and Ulcerative Colitis (UC), commonly have disru...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
TMS effects on circuit plasticity and drug seeking in mice.
Project Summary/Abstract Drug addiction is a leading cause of morbidity and mortality in the US. Opioid addiction in particular has become an epidemic with unprecedented overdose f...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Fluorescent nucleosides, nucleotides and oligonucleotides
PROJECT SUMMARY Nucleic acids and their building blocks play central roles in all cellular events and, as such, have immense impact on the emergence of diseases and, in turn, on hu...
The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome
The primary focus of this research proposal is the discovery and elucidation of novel biochemical pathways for the biosynthesis and metabolism of complex and simple carbohydrates i...
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality c...
Genomic and systemic approaches to evolutionary mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary Proposed investigations derive from two on-going R01 GM research programs.The study objectives include the design, synthesis & investigation of synthetic models...
Methods for Evolutionary Genomics Analysis
Summary/Abstract Continuing advances in nucleotide sequencing have resulted in the assembly of datasets containing large numbers of species, genes, and genomic segments.Phylogenomi...
Mechanisms for building and remodeling microtubule arrays
Project Summary Control of the internal organization of cells is essential to the form and function of all organisms.This ability rests largely on an intricate protein filament net...
Unlocking sequence-structure-function-disease relationships in large protein super-families
Project Summary Predicting disease phenotypes from genotypes is a grand challenge in biology and personalized medicine. Our long-term goal is to address this challenge using a comb...