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99,167 grants found
Showing 96,761 – 96,780 of 99,167 grants
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis. Most of our understanding of the mechanisms that control the transcript...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary Proposed investigations derive from two on-going R01 GM research programs. The study objectives include the design, synthesis & investigation of synthetic model...
Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
Genomic and systemic approaches to evolutionary mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
Modified Project Summary/Abstract SectionElevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurode...
CIRCADIAN PATTERN OF REST-ACTIVITY RHYTHMS AND BLOOD PRESSURE AND THE UNDERLYING
Project Summary: Nearly half of US adults present with HTN, one of the strongest risk factors for cardiovascular disease (CVD) and a leading cause of CVD mortality. Blood pressure...
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease
SUMMARY Protein sialylation is a post-translational modification produced by members of a family of sialyltransferases. We recently discovered that the resulting sialic acid linkag...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
Circuits driving spatial coding deficits in epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life. In rodent mod...
Visual Form Perception Produced by Electrically Stimulating Human Visual Cortex
Project Summary/Abstract Blindness disables millions of people across the world. In most cases, incurable blindness is caused by damage or dysfunction of the eye, retina, or optic...
Mechanisms and Consequences of Tau Internalization and Aggregation in the Central Nervous System
The aggregation of the protein tau occurs in a range of neurodegenerative diseases, including Alzheimer’s Disease1. The presence of tau aggregates, also known as neurofibrillary ta...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity. DC depletion abrogates tumor immunity and response to PD1 (αPD1) immunotherapy in many preclinical tu...
The impact of dietary zinc deficiency on innate immunity to lung infection
Zinc deficiency is a major risk factor for pneumonia, and is estimated to contribute to 16% of lower respiratory infections globally by the World Health Organization. Acinetobacter...
A Dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network
Protocol Title: A dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network Summary There is a substa...
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months. Chemotherapy in combination with surgery and radiation may modestly exten...
Supplement to Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...