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99,167 grants found
Showing 96,741 – 96,760 of 99,167 grants
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A. Fisher developed much of the mathematical and conceptual framework underlying the stud...
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
Project Summary The lack of specific targets for the treatment of triple-negative breast cancer (TNBC) is a major challenge, as many TNBCs do not respond to cytotoxic chemotherapie...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Deep tensor genomic imputation
Project Summary/Abstract High-throughput sequencing assays allow scientists to measure biochemical properties like transcription factor binding, histone modifications, and gene expr...
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer
ABSTRACT Head and neck cancer is currently treated by concomitant chemotherapy and radiation, but local recurrence and metastatic disease remain a concern. In particular, there is...
Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%. The mainstay of therapy in PDA is chemother...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthma
Asthma is characterized by excessive bronchoconstriction and a heightened sensitivity to inhaled irritants. Airway nerves control these responses. Recently, we found that eosinophi...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)
PROJECT SUMMARY Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-i...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life. Cognitive scientists have long believed that navigation...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States. Given the high percentage of cancer patients with co-existing atherosclerosis, t...
Sleep-dependent modulation of cerebrospinal fluid flow in aging
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Targeting Integrins in Lung Cancer
Lung cancer is the most common cause of cancer-related deaths in US veterans and worldwide. Molecularly targeted therapy and immunotherapy are two recent major breakthroughs in lun...
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to...