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99,167 grants found
Showing 96,721 – 96,740 of 99,167 grants
Re-engagement at Discharge (Re-Charge): Improving post-hospital outcomes for HIV-infected adults in Zambia
PROJECT SUMMARY In sub-Saharan African countries, HIV-infected patients suffer high rates of loss-to-follow-up and mortality following hospital admission. Among HIV-infected patien...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life. Cognitive scientists have long believed that navigation...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...
Commensal control of C. difficile virulence
Abstract: Clostridioides difficile, the etiology of pseudomembranous colitis, causes substantive morbidity, mortality and close to $5 billion/year in US healthcare costs. Commensal...
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
Project Summary The lack of specific targets for the treatment of triple-negative breast cancer (TNBC) is a major challenge, as many TNBCs do not respond to cytotoxic chemotherapie...
Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)
PROJECT SUMMARY Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-i...
The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome
The primary focus of this research proposal is the discovery and elucidation of novel biochemical pathways for the biosynthesis and metabolism of complex and simple carbohydrates i...
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
Branch vein occlusion (BVO) and diabetic retinopathy (DR) are major causes of new onset blindness in the US. These vascular disorders result in acellular capillaries secondary to i...
Fluorescent nucleosides, nucleotides and oligonucleotides
PROJECT SUMMARY Nucleic acids and their building blocks play central roles in all cellular events and, as such, have immense impact on the emergence of diseases and, in turn, on hu...
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
ABSTRACT Obesity is characterized by an excess of white adipose tissue (WAT), which has low metabolic activity. Recent studies demonstrate that cells in WAT can be driven toward a...
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Characterizing the primary olfactory subregions of the human amygdala
Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not wel...
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related Structure
Project Summary Glaucoma is the second leading cause of blindness globally, and is characterized by optic nerve damage that leads to the death of retinal ganglion cells with accomp...
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
The emergence of the neocortex and its capacity to be shaped by early sensory and motor experience is the hallmark of mammalian brain evolution. This remarkable plasticity allows t...
Global control of co-transcriptional splicing
Alternative splicing (AS) of human genes is pervasive and greatly expands the repertoire of protein and RNA products arising from the human genome. AS is critical for cellular diff...
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...