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99,167 grants found
Showing 96,701 – 96,720 of 99,167 grants
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill Children
SUMMARY Lower respiratory tract infections (LRTI) lead to more deaths each year in children than any other infectious disease category. Despite this, the underlying microbial patho...
Mechanism Shaping the Adhesion Landscape During Spinal Cord Development
PROJECT SUMMARY An important question in developmental biology is how cell fate specification and cell movement are coordinated during tissue morphogenesis to ensure all cell types...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality c...
Development of a rapid, pan fungal diagnostic assay
ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays spec...
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
Project Summary/Abstract Opportunistic fungal pathogens are a leading cause of healthcare associated bloodstream infections. Candida yeasts, specifically, cause 80-90% of biofilm-a...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Molecular and neural mechanisms of predator cue sensation
Understanding how animals make behavioral decisions is one of the biggest problems in neuroscience. The proposed study aims to understand molecular and neural mechanisms underlying...
Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate models
ABSTRACT The increasing number of bubonic/pneumonic plague cases globally (2010-2018), including the U.S., with a ~18% case fatality rate may reflect climate changes and a rodent c...
Regulation of spore peptidoglycan modification
Dr. Gabrielle Valles recently received her Ph.D. from the University of Connecticut, where she used NMR spectroscopy and X-ray crystallography to study the structure and function o...
Efficient estimation of auditory sensitivity and cognitive status using spoken-digit tests.
Project Summary/Abstract. Untreated age-related hearing loss (ARHL) is the most prevalent cause of reduced quality of life for persons 55 and older in the US. There are 30+ million...
Protein Networks as Synergistic Drivers of Membrane Remodeling
SUMMARY ABSTRACT: Administrative Supplement to Promote Diversity for R35GM139531 This proposal is for an administrative supplement to R35GM139531, to promote diversity through the...
The role and mechanism of necrosis in glioblastoma
Project Summary Gliomas are major primary brain tumors, of which glioblastomas (GBM) are the most common and aggressive forms. The poor outcome of traditional treatment for these t...
Mechanism Shaping the Adhesion Landscape During Spinal Cord Development
PROJECT SUMMARY An important question in developmental biology is how cell fate specification and cell movement are coordinated during tissue morphogenesis to ensure all cell types...
Molecular mechanisms of the mitochondrial permeability transition
The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochondrial inner membrane...
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically u...
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary/Abstract Type IA topoisomerases are ubiquitous in the three kingdoms of life, and play critically important roles in maintaining proper DNA topology during the vita...
Bromodomain-containing Protein 4 in Profibrotic Gene Expression and Lung Fibrosis
PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology. IPF is characterized by altered epigenetic state. Epigenetic alterations are poten...