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99,167 grants found
Showing 96,661 – 96,680 of 99,167 grants
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM’s heterogeneity and immunosuppres...
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
ABSTRACT Obesity is characterized by an excess of white adipose tissue (WAT), which has low metabolic activity. Recent studies demonstrate that cells in WAT can be driven toward a...
Mobile Ecological Momentary Diet Assessment: A Low Burden, Ecologically-Valid Approach to Measuring Dietary Intake in Near-Real Time
ABSTRACT The excessive intake of saturated fat and added sugars has been identified as a leading cause of premature mortality among adults in the U.S. contributing to approximately...
Gene Expression Regulatory Pathways and Retinal Ganglion Cell Neuroprotection
Loss of retinal ganglion cells (RGCs) in glaucoma and traumatic and other optic neuropathies results in permanent partial or complete blindness. Molecular mechanisms that may oppos...
Tryptophan derivatives in EHEC pathogenesis
PROJECT SUMMARY The colon contains tryptophan derivatives such as indole, which is a microbiota-derived signaling molecule, and the host-derived serotonin neurotransmitter that is...
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
Project Summary/Abstract Opportunistic fungal pathogens are a leading cause of healthcare associated bloodstream infections. Candida yeasts, specifically, cause 80-90% of biofilm-a...
Secondary data analysis of auditory steady-state response to explore the RDoC cognitive system constructs across the psychosis spectrum
Hallucinations and cognitive impairments associated with psychosis may be underpinned by N-methyl D- aspartate (NMDA) receptor hypofunction. Within the Research Domain Criteria (RD...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
Branch vein occlusion (BVO) and diabetic retinopathy (DR) are major causes of new onset blindness in the US. These vascular disorders result in acellular capillaries secondary to i...
Tissue factor-dependent coagulation in thrombosis and immune responses
Tissue factor (TF) is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of coagulation a...
Effects of cell-type specific brain stimulation in Alzheimer's model mice
Project Abstract. Alzheimer’s disease is the most common neurodegenerative disorder and the leading cause of dementia in the elderly. Aberrant brain activity has become recognized...
Characterizing the primary olfactory subregions of the human amygdala
Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not wel...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled “Fortilin, CTNNA3, and the Heart” is to test the central hypothesis that the inability of the failing heart to maintain...
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
Modified Project Summary/Abstract SectionElevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurode...
Glutamatergic basal forebrain neurons in aversion-resistant drinking
Project Summary A hallmark of alcohol use disorder is continued seeking and consumption of alcohol despite negative consequences. Neuroadaptations in corticostriatal projections to...
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions. Organisma...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...