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99,167 grants found
Showing 96,641 – 96,660 of 99,167 grants
Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing Data
PROJECT SUMMARY/ABSTRACT Growing advances in imaging and fluid-based assays of Alzheimer's disease (AD) biomarkers including amyloid, tau and neurodegeneration, confirm that A...
Spatiotemporal representation in ventral visual pathway
In natural vision, objects change appearance over time as they translate, rotate, become occluded or undergo complex transformations, e.g., during biological motion. In these dynam...
The role of lung lipofibroblasts in alveolar differentiation
Abstract A complication of preterm birth is underdeveloped lungs that lack surfactant and adequate gas exchange due to immature alveoli. Although recent advances have been made, th...
Central mechanisms of itch transmission
Abstract Chronic itch is an unmet medical problem associated with numerous skin, immune, and nervous diseases. An imbalance of excitatory and inhibitory transmission of itch may co...
Optical nanosensor for 3D force sensing in intact tissues of live animals
PROJECT SUMMARY Physical forces are known to impact cell functions in a fundamental way. While the study dates back some 100-years, the scientific interests have significantly incr...
Transcriptional Regulation of Lung Alveolar Regeneration
ABSTRACT The respiratory system is comprised of multiple unique and spatially distinct compartments that respond to injury and diseases states differently based on their cellular a...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
Develop an Artificial Intelligence-powered Smartphone App AICaries for Caries Detection in Children
Project Summary Early childhood caries (ECC) is the most common chronic childhood disease, with nearly 1.8 billion new cases per year globally. ECC afflicts approximately 55% of lo...
Point-of-care HPV mRNA test for cervical cancer screening in low-resource settings
Abstract: There is a significant need to improve global access to cervical cancer screening. Globally, approximately 570,000 women are diagnosed with and 311,000 women die from cer...
Mobile Health Tools to Promote Health in Adults with FASD
Project Summary/Abstract Adults with fetal alcohol spectrum disorders (FASD) experience many barriers to care. Research on the effects of prenatal alcohol exposure during adulthood...
Monitoring rapid guanosine signaling during ischemia
PROJECT SUMMARY Measuring dynamic guanosine signaling at the site of focal ischemia over time remains challenging to probe with existing technology yet knowledge of the dynamics, r...
Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Abstract Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with l...
The role of TNFR2 in ameliorating progressive encephalomyelitis
The mechanisms driving progressive multiple sclerosis (MS) remain enigmatic. Progression of MS correlates with the expression of the cytokine tumor necrosis factor (TNF) in cerebro...
Choline Polymorphisms in FASD
ABSTRACT This exploratory/developmental UH2 pilot application to CIFASD addresses the need for improved intervention in Fetal Alcohol Spectrum Disorder (FASD), a leading cause of l...
Central Regulation of Sodium Appetite via Synergistic Action of RAAS-sensitive Neurons
PROJECT SUMMARY The motivation to consume sodium, often referred to as "sodium (or salt) appetite", is a hard-wired neural response to sodium deficiency regulated by the...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related Structure
Project Summary Glaucoma is the second leading cause of blindness globally, and is characterized by optic nerve damage that leads to the death of retinal ganglion cells with accomp...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Project Summary/Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra-thermodynamic catalysis and fluorine sculptin...
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months. Chemotherapy in combination with surgery and radiation may modestly exten...
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill Children
SUMMARY Lower respiratory tract infections (LRTI) lead to more deaths each year in children than any other infectious disease category. Despite this, the underlying microbial patho...