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99,167 grants found
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Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease
SUMMARY Protein sialylation is a post-translational modification produced by members of a family of sialyltransferases.We recently discovered that the resulting sialic acid linkage...
Monitoring mosquito eco-systems and vector-control strategies using a stand-off optical sensor.
Monitoring mosquito ecosystems and vector-control strategies using a stand-off optical sensor. PI: B. Thomas ?NIH R21 Project Summary: Vector control strategies remain one of the m...
Evaluation of ovarian reserve, aging and fertility preservation in women with sickle cell disease
PROJECT SUMMARY/ABSTRACT Sickle cell disease (SCD) is one of the most common monogenic diseases affecting over 300,000 births worldwide and 1 in 400 of African descent. In the last...
Target Validation for I-BET151-Induced Differentiation in the African Trypanosome
PROJECT SUMMARY/ABSTRACT African trypanosomes are protozoan parasites that cause severe and often fatal disease in a variety of mammals in Sub-Saharan Africa, including humans (sle...
Tryptophan derivatives in EHEC pathogenesis
PROJECT SUMMARY The colon contains tryptophan derivatives such as indole, which is a microbiota-derived signaling molecule, and the host-derived serotonin neurotransmitter that is...
Tunneling nanotubes as an alternate route of Ebola virus dissemination
Ebola virus (EBOV) is an emerging, dangerous virus that causes increasingly more frequent outbreaks of a systemic, hemorrhagic disease in human populations. Approved countermeasure...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)
PROJECT SUMMARY Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-i...
AIDS-related HSV-1 retinal necrosis: Innate immunity and virus spread
Program Director/Principal Investigator (Last, First, Middle): Dix, Richard D Project Summary AIDS patients can develop a variant of acute retinal necrosis (ARN) designated progres...
Diversification of cell types in the Drosophila retina - Resubmission - 1
Summary The development of a complex organ such as the eye involves the specification of multiple distinct cell types and the integration of their functions. In Drosophila, the lig...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Elucidating the role of NK cells in Lewy body diseases
PROJECT SUMMARY/ABSTRACT Lewy body diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy are characterized by the accumulation of...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women. Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, a...
Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease
ABSTRACT / PROJECT SUMMARYHLA-B*51 in epistasis with the ERAP1 haplotype Hap10 confers the strongest currently known risk for Behcet’s Disease (BD) and Behcet’s Eye Disease (BED),...
MicroRNA as a target for fetal hemoglobin inducing agents in sickle cell disease
My long-term research goal is to develop effective pharmacological interventions that can alleviate disease progression and improve the quality of life for patients with sickle cel...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Functionally specialized components of disease heritability in ENCODE data
PROJECT SUMMARY/ABSTRACT Genetic discoveries from genome-wide association studies have led to important insights on human disease mechanisms. In particular, disease-associated vari...
Reactivation of Chronic Toxoplasmosis
Project Summary/Abstract Toxoplasma gondii is a widespread parasite of animals that cycles between cats, which shed infectious oocysts in their feces, and a variety of animals that...
High throughput CRISPR-mediated functional validation of regulatory elements
Project Summary The overarching goal of the proposed study is to functionally characterize a large number of candidate functional elements in the mammalian genome.The ENCODE projec...
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...