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99,167 grants found
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Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%.The mainstay of therapy in PDA is chemothera...
Mechanisms and Consequences of Tau Internalization and Aggregation in the Central Nervous System
The aggregation of the protein tau occurs in a range of neurodegenerative diseases, including Alzheimer?s Disease1.The presence of tau aggregates, also known as neurofibrillary tan...
Effects of aging on signal in noise processing
PROJECT SUMMARY/ABSTRACT Age-related hearing loss is a ubiquitous problem, estimated to affect up to one third of the population.This condition is much more detrimental than ?hard...
Gender-based differences in non-HIV STI testing among sexually active transgender and nonbinary persons: Bridging gaps in STI research
PROJECT ABSTRACT Research suggests that transgender (trans) populations, a diverse group of persons whose gender identity and/or expression differ from societal expectations associ...
Identifying the contribution of zinc limitation to antibiotic tolerance during S. aureus infection
Abstract Staphylococcus aureus is a major human pathogen responsible for numerous chronic and relapsing infections. These infections often do not respond to treatment, leading to a...
Methods for Evolutionary Genomics Analysis
Summary/Abstract Continuing advances in nucleotide sequencing have resulted in the assembly of datasets containing large numbers of species, genes, and genomic segments. Phylogenom...
The formation of kidney local microenvironment after acute kidney injury.
PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) is characterized by abrupt deterioration in kidney function, manifested by an increase in serum creatinine level, with or without...
Real-time visualization and precision targeting in transcranial magnetic stimulation
Project Summary Title: Real-time visualization and precision targeting in transcranial magnetic stimulation Transcranial magnetic stimulation (TMS) is a non-invasive device-based n...
Targeting Mitochondrial Function to Develop Novel Therapies for Neurodevelopmental Disorders
ABSTRACT We will identify potential new pharmacological therapies targeted to improve mitochondrial function in a class of cerebral cortical neurons thought to be compromised in mu...
RESISTANCE AND RESPONSE SIGNALING TO PARP1 INHIBITORS IN OVARIAN CANCER
The last twenty years have seen significant progress in ovarian cancer treatment, in particular for the women carrying pathogenic variants in BRCA1 or BRCA2.The foundation for this...
PET Imaging Agents for Protoporphyrin IX
Project Summary Primary brain tumor is a major central nervous system malignancy with 23,800 estimated total new cases in the US in 2017 resulting in 16,700 deaths. High grade glio...
Neoadjuvant PD-1 blockade in mismatch repair deficient rectal cancer
ABSTRACT Rectal cancer is treated with induction chemotherapy followed by chemoradiationand subsequentsurgery.Most patients who have undergone this sequential treatment approach ha...
Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Abstract Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with l...
Spatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum
PROJECT SUMMARY Understanding the cellular biology and neurophysiology of sensory processing in the spinal cord is fundamental to advancing medical intervention in the treatment of...
ZBP1 activation
Project Summary/Abstract The putative nucleotide sensor ZBP1 can trigger necroptotic cell death or transcriptional responses, and genetic studies indicate that this pathway is requ...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
Project Summary/Abstract Opportunistic fungal pathogens are a leading cause of healthcare associated bloodstream infections.Candida yeasts, specifically, cause 80-90% of biofilm-as...
Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate models
ABSTRACT The increasing number of bubonic/pneumonic plague cases globally (2010-2018), including the U.S., with a ~18% case fatality rate may reflect climate changes and a rodent c...
Development of a rapid, pan fungal diagnostic assay
ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays spec...
Commensal control of C. difficile virulence
Abstract: Clostridioides difficile, the etiology of pseudomembranous colitis, causes substantive morbidity, mortality and close to $5 billion/year in US healthcare costs.Commensals...