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99,167 grants found
Showing 96,561 – 96,580 of 99,167 grants
Racial Bias in a VA Algorithm for High-Risk Veterans
PROJECT SUMMARY African-American Veterans are at particular risk of adverse outcomes, including mortality and hospitalization, due to adverse social determinants of health (SDoH) i...
Cardiac Lineage-Specific Molecular Mechanisms of Heart Failure
Project Summary The heart consists of a multitude of diverse cardiac cell types, including but not limited to cardiomyocytes, cardiac fibroblasts, epicardial cells, endothelial/end...
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in traumatized people with posttra...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
A Dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network
Protocol Title: A dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network Summary There is a substa...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies....
Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple Models
Abstract The tau protein is a key hallmark of Alzheimer’s disease and other tauopathies but its pathogenesis is not well understood. Targeting its toxicity and/or aggregates with a...
Unexpected Function of Inflammasomes in Axon Pruning: Focus on NLRP1
Project Summary/Abstract Neurons are capable of activating pathways that induce either the degeneration of the entire cell by apoptosis or to selectively degenerate only the axons....
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE
Project abstract Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE). However, despite these ins...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome during...
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
Abstract Alzheimer’s disease (AD) affects over 5 million Americans and is expected to affect 2-3-fold more in the next few decades. AD is associated with aggregation of amyloid-bet...
Delineating mechanisms of skeletal fragility in older adults with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Skeletal fragility is a recently recognized complication of Type 1 diabetes (T1D), and is of particular concern among older adults. Patients with T1D hav...
Targeting tumor architecture as a novel therapeutic strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most chemorefractory cancers among solid tumors. Even with the most effective chemotherapy (i.e., FOLFIRINOX), only 30% of PDA...
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease
SUMMARY Protein sialylation is a post-translational modification produced by members of a family of sialyltransferases. We recently discovered that the resulting sialic acid linkag...
Genomic and systemic approaches to evolutionary mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Commensal-specific T cell function in skin wound repair
PROJECT SUMMARY Our understanding of immunity largely stems from models of infection with pathogenic microbes.However, the vast majority of microbial-immune encounters occur as a s...
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer
ABSTRACT Head and neck cancer is currently treated by concomitant chemotherapy and radiation, but local recurrence and metastatic disease remain a concern.In particular, there is a...
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
Summary Amyotrophic lateral sclerosis (ALS) is a life-threatening, neurodegenerative disease that causes the degeneration of motor neurons in the brain and spinal cord. There are c...
Evaluating the role of P53 pathways in malaria
Project Summary/Abstract Malaria caused by the Plasmodium parasite remains a global health threat, affecting ~200 million people and leading to more than 400,000 deaths per year.Un...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States.Given the high percentage of cancer patients with co-existing atherosclerosis, th...