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99,167 grants found
Showing 96,541 – 96,560 of 99,167 grants
The role and mechanism of necrosis in glioblastoma
Project Summary Gliomas are major primary brain tumors, of which glioblastomas (GBM) are the most common and aggressive forms. The poor outcome of traditional treatment for these t...
ZBP1 activation
Project Summary/Abstract The putative nucleotide sensor ZBP1 can trigger necroptotic cell death or transcriptional responses, and genetic studies indicate that this pathway is requ...
Tissue factor-dependent coagulation in thrombosis and immune responses
Tissue factor (TF) is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of coagulation a...
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may...
Monitoring rapid guanosine signaling during ischemia
PROJECT SUMMARY Measuring dynamic guanosine signaling at the site of focal ischemia over time remains challenging to probe with existing technology yet knowledge of the dynamics, r...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity. DC depletion abrogates tumor immunity and response to PD1 (αPD1) immunotherapy in many preclinical tu...
Understanding affective processing of scientific evidence to promote informed choice for breast cancer screening
Project Summary/Abstract Cancer screening for the right patients at the right level of cancer risk can save lives, but over the last several years many expert groups have de-intens...
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary/Abstract Type IA topoisomerases are ubiquitous in the three kingdoms of life, and play critically important roles in maintaining proper DNA topology during the vita...
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Project Summary While activated T cells cross the blood-brain barrier (BBB), immunotherapy has yet to be harnessed for targeted therapy due to GBM’s heterogeneity and immunosuppres...
Cell Type Specific Genetic Manipulation to Dissect Cholinergic Interneuron Function and Plasticity in a Symptomatic Model of DYT1 Dystonia
Project Summary/Abstract Cholinergic neurons (ChIs) are a central but poorly understood element of striatal circuitry. A considerable literature strongly implicates ChI dysfunction...
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...
Neuronal Circuit Maintenance in Healthy Aging
Project Summary The overarching goal of this study is to identify new mechanisms that preserve neuronal function with age. As the world's aging population steadily increases,...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells. MF play a key role in shaping the...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry
ABSTRACT Alzheimer disease (AD) is the leading cause of dementia in older adults and occurs in all ethnic and racial groups. Genetic studies of AD have mostly been performed in non...
Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos
Project Summary/Abstract This project is directly aligned with the NIA’s strategic goals of 1) developing improved approaches for the early detection and diagnosis of disabling ill...
Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease
PROJECT SUMMARY Subthalamic deep brain stimulation (DBS) can significantly improve the motor symptoms and quality of life of patients with Parkinson’s disease (PD). Recent advances...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women. Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, a...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...