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99,167 grants found
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Sleep-dependent modulation of cerebrospinal fluid flow in aging
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
Montessori Approaches in Person-Centered Care (MAP-VA): An Effectiveness-Implementation Trial in Community Living Centers
Background: VA Community Living Center (CLC) staff struggle to address behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as s...
Montessori Approaches in Person-Centered Care (MAP-VA): An Effectiveness-Implementation Trial in Community Living Centers
Background: VA Community Living Center (CLC) staff struggle to address behavioral and neuropsychiatric symptoms of Veterans with dementia and serious mental illness (SMI) such as s...
Blood-brain-barrier and white matter mechanisms underlying dementia
Abstract White matter (WM) damage has increasingly been recognized as an important contributing factor to neurodegeneration and dementia, however, little is known of the specific m...
Defining the molecular basis of oncogene-induced replication stress
PROJECT SUMMARY/ABSTRACT Environmental genotoxic carcinogens target numerous proto-oncogenes (and tumor-suppressor genes) to induce point mutations in key codons, leading to oncoge...
Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Abstract Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with l...
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
Project Summary The PI Batista from Yale and co-investigators (Lisi, Brown University, and Palermo, UC Riverside) will investigate allosteric pathways in the CRISPR-Cas9 system – c...
A hybrid effectiveness-implementation trial of a school based executive function treatment for transition age youth with autism
PROJECT SUMMARY The proposed study is highly relevant to the 2017 Interagency Autism Coordinating Committee priorities to improve transition to adulthood in autism spectrum disorde...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...
Mechanisms for building and remodeling microtubule arrays
Project Summary Control of the internal organization of cells is essential to the form and function of all organisms. This ability rests largely on an intricate protein filament ne...
Regulation of spore peptidoglycan modification
SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control. In order for C. diffi...
Optical Analogs to MRI Contrast Agents for Surgical Guidance of Brain Tumor Resection
ABSTRACT Surgical resection is a fixture in the treatment of intracranial tumors, and there is mounting data indicating that overall and progression-free survival improve for gross...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...
Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages
SUMMARY Time is a problem for biologists, especially for those interested in cancer, stem cell, and developmental biology. Whereas cellular processes occur in real time, we most of...
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill Children
SUMMARY Lower respiratory tract infections (LRTI) lead to more deaths each year in children than any other infectious disease category. Despite this, the underlying microbial patho...
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions. Organisma...
Drug abuse and HIV-associated pulmonary vascular injury
PROJECT SUMMARY University of Kansas Medical Center Research Institute, Inc. Advancement in antiretroviral therapy (ART) has clearly led to a serious increase in the prevalence of...
Characterizing the Complexity of Advanced Cancer Pain in the Home Context by Leveraging Smart Health Technology
Project Summary Cancer pain is complex, prevalent and has serious consequences for patients, family caregivers and healthcare systems. Inadequately managed cancer pain can be parti...
Spatiotemporal representation in ventral visual pathway
In natural vision, objects change appearance over time as they translate, rotate, become occluded or undergo complex transformations, e.g., during biological motion. In these dynam...
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis
Project Summary/Abstract: Pulmonary fibrosis (PF) is a rare degenerative disease characterized by progressive lung stiffening, resulting in death within 3-5-years of diagnosis. Com...