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99,167 grants found
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The Effect of Screening and Referral for Social Determinants of Health on Veterans' Outcomes
Background: Despite medical advances, up to 70% of health outcomes are due to social determinants of health (SDoH) - the conditions in which people live and work that shape whether...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Neuronal Circuit Maintenance in Healthy Aging
Project Summary The overarching goal of this study is to identify new mechanisms that preserve neuronal function with age. As the world's aging population steadily increases,...
The impact of dietary zinc deficiency on innate immunity to lung infection
PROJECT SUMMARY Candidate: My postdoctoral research thus far focused on the effects of host dietary zinc on bacterial pathogenesis during Acinetobacter baumannii pneumonia in Dr. E...
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)
Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is o...
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically u...
B-cell innate and adaptive protective immunity to SARS-CoV-2
The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic. The most important question is why some individuals produce rapid protective antibodies...
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in traumatized people with posttra...
CIRCADIAN PATTERN OF REST-ACTIVITY RHYTHMS AND BLOOD PRESSURE AND THE UNDERLYING
Project Summary: Nearly half of US adults present with HTN, one of the strongest risk factors for cardiovascular disease (CVD) and a leading cause of CVD mortality. Blood pressure...
Unlocking sequence-structure-function-disease relationships in large protein super-families
PROJECT SUMMARY (unchanged) Predicting disease phenotypes from genotypes is a grand challenge in biology and personalized medicine. Our long-term goal is to address this challenge...
Equipment Supplement: Genomic and Systemic Approaches of Evolutionary Mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
PROJECT SUMMARY / ABSTRACT Elevated levels of reactive oxygen species (ROS) are linked to severe pathological conditions causing cardiomyopathies and neurodegeneration. Today we ca...
Administrative Supplement to SMART NANPs: new molecular platform for communication with human immune system and modulation of therapeutic responses
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Mechanisms for building and remodeling microtubule arrays
PROJECT SUMMARY The Project Summary is contained within the Research Strategy.
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Drug abuse and HIV-associated pulmonary vascular injury
Project Summary This administrative supplement proposal is to examine if the circulating endothelial-derived small extracellular vesicles (EVs) can be leveraged as a non-invasive b...
The impact of dietary zinc deficiency on innate immunity to lung infection
PROJECT SUMMARY Candidate: My postdoctoral research thus far focused on the effects of host dietary zinc on bacterial pathogenesis during Acinetobacter baumannii pneumonia in Dr. E...
Cardiac Lineage-Specific Molecular Mechanisms of Heart Failure
Project Summary The heart consists of a multitude of diverse cardiac cell types that form cardiac structures critical for maintaining heart function. These cell populations include...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...