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99,167 grants found
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Unlocking sequence-structure-function-disease relationships in large protein super-families
Project Summary Predicting disease phenotypes from genotypes is a grand challenge in biology and personalized medicine. Our long-term goal is to address this challenge using a comb...
The gut endoderm: origin, formation and fate
PROJECT SUMMARY / ABSTRACT The gut endoderm is the precursor tissue of the respiratory and digestive tracts, and their associated visceral organs. In this project we will use a sui...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
ZBP1 activation
Project Summary/Abstract The putative nucleotide sensor ZBP1 can trigger necroptotic cell death or transcriptional responses, and genetic studies indicate that this pathway is requ...
Transcriptional Regulation of Lung Alveolar Regeneration
ABSTRACT The respiratory system is comprised of multiple unique and spatially distinct compartments that respond to injury and diseases states differently based on their cellular a...
Commensal-specific T cell function in skin wound repair
PROJECT SUMMARY Our understanding of immunity largely stems from models of infection with pathogenic microbes. However, the vast majority of microbial-immune encounters occur as a...
Role of Erbb3 kinase activity in colorectal tumorigenesis.
The overarching goals of this proposal are to determine if Erbb3 kinase plays a critical role in colorectal tumorigenesis and to test if colorectal cancer with oncogenic Erbb3 muta...
Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%. The mainstay of therapy in PDA is chemother...
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled “Fortilin, CTNNA3, and the Heart” is to test the central hypothesis that the inability of the failing heart to maintain...
Trans-omic analysis of epicardial adipose tissue in atrial fibrillation
Project Summary Atrial fibrillation (AF) is the most common arrhythmia affecting well over 2 million people in the US with projections that it will affect 8-12 million people by 20...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
The emergence of the neocortex and its capacity to be shaped by early sensory and motor experience is the hallmark of mammalian brain evolution. This remarkable plasticity allows t...
PrEP adherence-concentration thresholds associated with HIV protection among African women
ABSTRACT African women are disproportionately affected with HIV and have elevated risk of acquiring HIV in pregnancy. Pre-exposure prophylaxis (PrEP) is a potent HIV prevention str...
Polyunsaturated fatty acids and colorectal tumor risk: a molecular and genetic epidemiology study
PROJECT SUMMARY/ABSTRACT Arachidonic acid, a long-chain ω-6 polyunsaturated fatty acid (PUFA), has been demonstrated to affect carcinogenesis in animal and in vitro studies. The ef...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Mitochondria targeting for Alzheimer's Disease
PROJECT SUMMARY Decreased energy metabolism is an invariant feature of the brains of Alzheimer’s disease (AD) patients, yet the specific use of pharmacologic strategies to manipula...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Delineating mechanisms of skeletal fragility in older adults with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Skeletal fragility is a recently recognized complication of Type 1 diabetes (T1D), and is of particular concern among older adults. Patients with T1D hav...
The role of obscurin and Obsl1 as key determinants for diastolic function
Project Summary: The role of obscurin and Obsl1 as key determinants for diastolic function Cardiovascular disease (CVD) remains a leading cause of mortality in the US, with heart f...