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99,167 grants found
Showing 96,341 – 96,360 of 99,167 grants
Circuits driving spatial coding deficits in epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life. In rodent mod...
Monitoring rapid guanosine signaling during ischemia
PROJECT SUMMARY Measuring dynamic guanosine signaling at the site of focal ischemia over time remains challenging to probe with existing technology yet knowledge of the dynamics, r...
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
Project Summary The PI Batista from Yale and co-investigators (Lisi, Brown University, and Palermo, UC Riverside) will investigate allosteric pathways in the CRISPR-Cas9 system – c...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Structure-Function Studies of Aquaporin 0 in Lens Development and Physiology
Project Summary Cataract, the opacification of the eye lens, is the leading cause of blindness worldwide. Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, functi...
Muller cell activation and remodeling in AMD.
Age-related macular degeneration (AMD) is a complex, multifactorial disease. I have recently reported subretinal Müller cell membranes in areas of geographic atrophy (GA). These me...
Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome
PROJECT SUMMARY Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. Peroxisomes participate in a number of biochemical pathways including catabolis...
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer
ABSTRACT Head and neck cancer is currently treated by concomitant chemotherapy and radiation, but local recurrence and metastatic disease remain a concern. In particular, there is...
Mesenchymal modulation of epithelial metaplasia in lung fibrosis
Project Summary/Abstract Aberrant epithelial reprogramming can take the form of metaplasia, characterized by the appearance of mature cell types that are not normally present at th...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States. Given the high percentage of cancer patients with co-existing atherosclerosis, t...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Molecular signaling mechanisms controlling Cryptosporidium proliferation and development
Project Abstract Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death among young children living in resource-poor settings. In the US, Cryptospori...
Cell Type Specific Genetic Manipulation to Dissect Cholinergic Interneuron Function and Plasticity in a Symptomatic Model of DYT1 Dystonia
Project Summary/Abstract Cholinergic neurons (ChIs) are a central but poorly understood element of striatal circuitry. A considerable literature strongly implicates ChI dysfunction...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women. Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, a...
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A. Fisher developed much of the mathematical and conceptual framework underlying the stud...
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
How Do Synaptic Connections Change in Demyelinating Disease?
Schafer, Dorothy P. Project Summary Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), which has a profound, currently intractabl...
Understanding affective processing of scientific evidence to promote informed choice for breast cancer screening
Project Summary/Abstract Cancer screening for the right patients at the right level of cancer risk can save lives, but over the last several years many expert groups have de-intens...
Global control of co-transcriptional splicing
Alternative splicing (AS) of human genes is pervasive and greatly expands the repertoire of protein and RNA products arising from the human genome. AS is critical for cellular diff...
Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos
Project Summary/Abstract This project is directly aligned with the NIA’s strategic goals of 1) developing improved approaches for the early detection and diagnosis of disabling ill...