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99,167 grants found
Showing 96,321 – 96,340 of 99,167 grants
Racial Bias in a VA Algorithm for High-Risk Veterans
PROJECT SUMMARY African-American Veterans are at particular risk of adverse outcomes, including mortality and hospitalization, due to adverse social determinants of health (SDoH) i...
Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease
ABSTRACT / PROJECT SUMMARYHLA-B*51 in epistasis with the ERAP1 haplotype Hap10 confers the strongest currently known risk for Behcet’s Disease (BD) and Behcet’s Eye Disease (BED),...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...
Phase II trial of GM-CSF/sargramostim in Alzheimer's Disease
PROJECT ABSTRACT Alzheimer’s disease (AD) treatments designed to target the amyloid-beta peptide have shown encouraging results in transgenic animal models but less encouraging res...
Capacity limits in the neural circuitry of visual word recognition
Project Summary / Abstract For most literate adults, reading feels effortless. However, visual word recognition is a complex process performed by specialized circuits in the brain,...
TMS effects on circuit plasticity and drug seeking in mice.
Project Summary/Abstract Drug addiction is a leading cause of morbidity and mortality in the US. Opioid addiction in particular has become an epidemic with unprecedented overdose f...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Neutralizing the degenerate disc microenvironment to enhance the efficacy of therapeutic stem cells
Abstract Low back pain is the leading cause of disability in the United States, with an estimated socioeconomic cost exceeding $100 billion each year. Intervertebral disc degenerat...
Drug abuse and HIV-associated pulmonary vascular injury
PROJECT SUMMARY University of Kansas Medical Center Research Institute, Inc. Advancement in antiretroviral therapy (ART) has clearly led to a serious increase in the prevalence of...
High-sensitivity Immunomagnetic System for "Liquid Biopsy" of Alzheimer's Disease
Project Summary Alzheimer’s disease (AD) is a major healthcare and social-economic burden. With effective treatment yet to be developed, the early detection at the prodromal stage...
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
Project Summary Carriers of the apolipoprotein E (APOE) ε4 gene are at a significantly increased risk for developing Alzheimer’s disease (AD). Although numerous theories have been...
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. This large affected population and the severe...
The role of TNFR2 in ameliorating progressive encephalomyelitis
The mechanisms driving progressive multiple sclerosis (MS) remain enigmatic. Progression of MS correlates with the expression of the cytokine tumor necrosis factor (TNF) in cerebro...
Development of Poly (pro-curcumin) Polymer Coatings to Improve Cortical Electrode Biocompatibility
This application aims to create innovative polymer coatings to improve intracortical microelectrode biocompatibility. Following intracortical microelectrode implantation, an inflam...
Effects of aging on signal in noise processing
PROJECT SUMMARY/ABSTRACTAge-related hearing loss is a ubiquitous problem, estimated to affect up to one third of the population. This condition is much more detrimental than ‘hard...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Evaluating the role of P53 pathways in malaria
Project Summary/Abstract Malaria caused by the Plasmodium parasite remains a global health threat, affecting ~200 million people and leading to more than 400,000 deaths per year. U...
1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Project Summary/Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra-thermodynamic catalysis and fluorine sculptin...
Central mechanisms of itch transmission
Abstract Chronic itch is an unmet medical problem associated with numerous skin, immune, and nervous diseases. An imbalance of excitatory and inhibitory transmission of itch may co...