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99,167 grants found
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Inflammation Changes Associated with Interoception Changes following Vibroacoustically Augmented Breath Focused Mindfulness for Dissociation
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in trauma-exposed people with post...
Acquisition of Equipment for Structural Studies of Macromolecular Assemblies Using Cryo-EM
PROJECT SUMMARY The experimental research under the parent R35 grant focuses on time-resolved (TR) cryo-electron microscopy (cryo-EM) to study short-lived states during translation...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits for cancer recovery and risk reduction for futur...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease
PROJECT SUMMARY Subthalamic deep brain stimulation (DBS) can significantly improve the motor symptoms and quality of life of patients with Parkinson’s disease (PD). Recent advances...
Defining the molecular basis of oncogene-induced replication stress
PROJECT SUMMARY/ABSTRACT Environmental genotoxic carcinogens target numerous proto-oncogenes (and tumor-suppressor genes) to induce point mutations in key codons, leading to oncoge...
Characterizing the Complexity of Advanced Cancer Pain in the Home Context by Leveraging Smart Health Technology
Project Summary Cancer pain is complex, prevalent and has serious consequences for patients, family caregivers and healthcare systems. Inadequately managed cancer pain can be parti...
A hybrid effectiveness-implementation trial of a school based executive function treatment for transition age youth with autism
PROJECT SUMMARY The proposed study is highly relevant to the 2017 Interagency Autism Coordinating Committee priorities to improve transition to adulthood in autism spectrum disorde...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...
Commensal-specific T cell function in skin wound repair
PROJECT SUMMARY Our understanding of immunity largely stems from models of infection with pathogenic microbes. However, the vast majority of microbial-immune encounters occur as a...
Spatiotemporal representation in ventral visual pathway
In natural vision, objects change appearance over time as they translate, rotate, become occluded or undergo complex transformations, e.g., during biological motion. In these dynam...
CIRCADIAN PATTERN OF REST-ACTIVITY RHYTHMS AND BLOOD PRESSURE AND THE UNDERLYING
Project Summary: Nearly half of US adults present with HTN, one of the strongest risk factors for cardiovascular disease (CVD) and a leading cause of CVD mortality. Blood pressure...
Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Abstract Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with l...
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis
Project Summary/Abstract: Pulmonary fibrosis (PF) is a rare degenerative disease characterized by progressive lung stiffening, resulting in death within 3-5-years of diagnosis. Com...
B-cell innate and adaptive protective immunity to SARS-CoV-2
The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic. The most important question is why some individuals produce rapid protective antibodies...
Gene Expression Regulatory Pathways and Retinal Ganglion Cell Neuroprotection
Loss of retinal ganglion cells (RGCs) in glaucoma and traumatic and other optic neuropathies results in permanent partial or complete blindness. Molecular mechanisms that may oppos...
High-throughput screening for modulators of vascular fat transport to treat and prevent diabetes
PROJECT SUMMARY / ABSTRACT Insulin resistance (IR) in skeletal muscle and other tissues is obligatory for the development of type 2 diabetes. Excess accumulation of incompletely ox...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Development of Poly (pro-curcumin) Polymer Coatings to Improve Cortical Electrode Biocompatibility
This application aims to create innovative polymer coatings to improve intracortical microelectrode biocompatibility. Following intracortical microelectrode implantation, an inflam...