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99,167 grants found
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WildCam: A Privacy Conscious Wearable Eating Detection Camera People will Actually Wear in the Wild
Project Summary Behavioral interventions for weight loss include self-monitoring and self-report of diet. However, few people adhere to self-monitoring because they believe it will...
Delineating mechanisms of skeletal fragility in older adults with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Skeletal fragility is a recently recognized complication of Type 1 diabetes (T1D), and is of particular concern among older adults. Patients with T1D hav...
Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
Molecular and neural mechanisms of predator cue sensation
Understanding how animals make behavioral decisions is one of the biggest problems in neuroscience. The proposed study aims to understand molecular and neural mechanisms underlying...
Characterizing the Complexity of Advanced Cancer Pain in the Home Context by Leveraging Smart Health Technology
Project Summary Cancer pain is complex, prevalent and has serious consequences for patients, family caregivers and healthcare systems. Inadequately managed cancer pain can be parti...
Maintenance of synapses during adulthood in Drosophila
PROJECT SUMMARY The goal of this proposal is to identify genes that regulate an age-dependent change in active zones (AZs) that causes an age-dependent decline in neuron function....
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. This large affected population and the severe...
Identifying the contribution of zinc limitation to antibiotic tolerance during S. aureus infection
Abstract Staphylococcus aureus is a major human pathogen responsible for numerous chronic and relapsing infections. These infections often do not respond to treatment, leading to a...
Evaluating the role of P53 pathways in malaria
Project Summary/Abstract Malaria caused by the Plasmodium parasite remains a global health threat, affecting ~200 million people and leading to more than 400,000 deaths per year. U...
Cell Type Specific Genetic Manipulation to Dissect Cholinergic Interneuron Function and Plasticity in a Symptomatic Model of DYT1 Dystonia
Project Summary/Abstract Cholinergic neurons (ChIs) are a central but poorly understood element of striatal circuitry. A considerable literature strongly implicates ChI dysfunction...
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease
SUMMARY Protein sialylation is a post-translational modification produced by members of a family of sialyltransferases. We recently discovered that the resulting sialic acid linkag...
Metal nutrients and metallophore-likemolecules for a fungal pathogen
Transition metals including Cu, Mn, Zn and Fe are essential nutrients for all life forms. Microbial pathogens face challenges in acquiring these vital elements, as the host deliber...
The gut endoderm: origin, formation and fate
PROJECT SUMMARY / ABSTRACT The gut endoderm is the precursor tissue of the respiratory and digestive tracts, and their associated visceral organs. In this project we will use a sui...
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)
Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is o...
Engineered Biomaterial for Endoscopic Treatment of Airway Fibrosis
PROJECT SUMMARYIn this proposal, our primary goal is to explore the optimization of a biomaterial to prevent the recurrence of fibrosis and promote regeneration of mucosal epitheli...
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE
Project abstract Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE). However, despite these ins...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
Project Summary: Salt-sensitive hypertension is an independent predictor of death due to cardiovascular disease (CVD), but the mechanisms are poorly understood. Most of the researc...
Immune Mechanisms Regulating Cardiac Remodeling
Summary Cardiovascular disease is the number cause of death in the United States. Most cardiovascular diseases are associated with an increase in myocardial mass or cardiac hypertr...
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
The emergence of the neocortex and its capacity to be shaped by early sensory and motor experience is the hallmark of mammalian brain evolution. This remarkable plasticity allows t...