Browse All Grants
99,167 grants found
Showing 96,261 – 96,280 of 99,167 grants
Effects of aging on signal in noise processing
PROJECT SUMMARY/ABSTRACTAge-related hearing loss is a ubiquitous problem, estimated to affect up to one third of the population. This condition is much more detrimental than ‘hard...
Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity
PROJECT SUMMARY Macrophages (MF) are one of the largest immune cell components of tumor lesions, where their numbers can even exceed cancer cells. MF play a key role in shaping the...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to...
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
Summary Amyotrophic lateral sclerosis (ALS) is a life-threatening, neurodegenerative disease that causes the degeneration of motor neurons in the brain and spinal cord. There are c...
RESISTANCE AND RESPONSE SIGNALING TO PARP1 INHIBITORS IN OVARIAN CANCER
The last twenty years have seen significant progress in ovarian cancer treatment, in particular for the women carrying pathogenic variants in BRCA1 or BRCA2. The foundation for thi...
Neoadjuvant PD-1 blockade in mismatch repair deficient rectal cancer
ABSTRACT Rectal cancer is treated with induction chemotherapy followed by chemoradiationand subsequentsurgery. Most patients who have undergone this sequential treatment approach h...
Monitoring mosquito eco-systems and vector-control strategies using a stand-off optical sensor.
Monitoring mosquito ecosystems and vector-control strategies using a stand-off optical sensor. PI: B. Thomas – NIH R21 Project Summary: Vector control strategies remain one of the...
Bone Morphogenic Protein signaling in Th/Treg lineage specification
Abstract The transforming growth factor-β (TGF-β) family cytokines regulate cell differentiation and morphogenesis, cell proliferation and migration, epithelial-to-mesenchymal tran...
ZBP1 activation
Project Summary/Abstract The putative nucleotide sensor ZBP1 can trigger necroptotic cell death or transcriptional responses, and genetic studies indicate that this pathway is requ...
Quantifying the spectrum and dynamics of B-cell binding avidity in response to influenza
PROJECT SUMMARY Activation, clonal expansion, and affinity maturation of antigen-specific B cells are considered the hallmarks of adaptive immunity; hence, the assessment of B cell...
Molecular signaling mechanisms controlling Cryptosporidium proliferation and development
Project Abstract Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death among young children living in resource-poor settings. In the US, Cryptospori...
Reactivation of Chronic Toxoplasmosis
Project Summary/Abstract Toxoplasma gondii is a widespread parasite of animals that cycles between cats, which shed infectious oocysts in their feces, and a variety of animals that...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies....
Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome
PROJECT SUMMARY Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. Peroxisomes participate in a number of biochemical pathways including catabolis...
Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos
Project Summary/Abstract This project is directly aligned with the NIA’s strategic goals of 1) developing improved approaches for the early detection and diagnosis of disabling ill...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT
Summary Aptamers are oligonucleotide-based receptors that can be isolated from the large libraries of random oligonucleotides to bind to small molecules. In the past, our team deve...
Unlocking sequence-structure-function-disease relationships in large protein super-families
Project Summary Predicting disease phenotypes from genotypes is a grand challenge in biology and personalized medicine. Our long-term goal is to address this challenge using a comb...
Drug overdose out-of-hospital cardiac arrest events in the United States: Insights from a large data registry
PROJECT SUMMARY Drug overdose out-of-hospital cardiac arrest (OD-OHCA) is a serious and growing public health threat that is wholly understudied. Currently, we lack a broadly-repre...